What is this study trying to find out about vision after cataract surgery?

This study is evaluating how different types of intraocular lenses affect visual performance in low light and low contrast conditions. Researchers want to understand the impact of these lenses on vision, nighttime visual disturbances, and patient satisfaction. The study is led by Dr. Daniel H. Chang, MD and aims to improve understanding of vision outcomes after lens implants.

Who may be eligible for this vision clinical trial?

Adults aged 22 years or older who have had cataract surgery with artificial lenses implanted in both eyes may be eligible. Participants must be able to complete vision tests and questionnaires in English. People with certain eye conditions or prior eye surgeries may not qualify. Please review eligibility criteria for more details.

Is there any cost to participate in this vision clinical trial?

Study-related care, including all vision tests and questionnaires, is provided at no cost. Personal travel expenses may vary and are not guaranteed to be covered. Participants can expect study visits to focus on eye exams and vision assessments at no charge.

Actively Recruiting

Age: 22Years +

All Genders

ID07213167

Clinical Evaluation of Low Contrast Defocus Curves, Low Light Photic Phenomena, and Dysphotopsia Profiles in Pseudophakic Patients

Led by Dr. Daniel H. Chang, MD · Updated on 2026-04-06

120

Participants Needed

Research Sites

4 weeks

Total Duration

AI-Summary

What this Trial Is About

Researchers are studying how different types of intraocular lenses IOLs affect visual performance in low light and low contrast conditions after cataract surgery. The study compares three IOL models to understand their impact on vision, nighttime side effects, and patient satisfaction. The goal is to better correlate objective measures with patient-reported visual experiences, including dysphotopsia, which are visual disturbances like glare or halos. Participants will be grouped based on the type of Tecnis intraocular lens they have received Monofocals, Symfony Optiblue, or Odyssey models. They will complete questionnaires about their vision and undergo a variety of visual tests using specialized devices. These tests include measuring visual acuity, contrast sensitivity, pupil size, defocus curves, and photic phenomena under different lighting and color conditions. The study also includes slit-lamp exams and intraocular pressure measurements. During the study visit, participants will answer two vision questionnaires in random order and undergo multiple eye exams and tests to assess their visual function and symptoms. Researchers will track outcomes such as low contrast defocus curve, halometry, and patient questionnaire results. Secondary measures include best corrected distance visual acuity, contrast sensitivity, pupil size, and evaluation for posterior capsular opacification or need for YAG capsulotomy. The study begins in September 2025 and will continue through August 2026.

CONDITIONS

Brief Title

Clinical Evaluation of Low Contrast Visual Performance and Low Light Phenomena in Patients With Various Intraocular Lens Implants

Who Can Participate

Age: 22Years +

All Genders

Eligibility Criteria

You may qualify if you...

Minimum 22 years of age
Bilateral pseudophakia, at least 3 months after intraocular lens implantation with one of the study IOL models in at least one eye
Willingness and cognitive ability to comply with examination procedures
Signed informed consent and HIPAA authorization or equivalent privacy documentation
Ability to understand and respond to questionnaires in English

You will not qualify if you...

Clinically significant pupil abnormalities such as non-reactive, fixed, or abnormally shaped pupils
Inability to focus or fixate for long periods (e.g., due to strabismus or nystagmus)
Uncorrected distance visual acuity worse than 20/25 in either eye
Prior corneal refractive surgery or intraocular surgery (except minor procedures deemed acceptable by the investigator)
Posterior capsular opacification worse than grade 1+
Eye conditions that may affect vision or contrast sensitivity as judged by the investigator

Research Team

Brittany M Camirand

Daniel H Chang, MD

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