What is this study trying to find out about facial defect reconstruction?

This study is evaluating how well patient-specific 3D-printed titanium implants work for reconstructing facial bone defects and improving facial appearance. Researchers want to see if these customized implants provide better fit, function, and aesthetics compared to standard methods. The study is sponsored by Latakia University.

Who may be eligible for this facial reconstruction clinical trial?

Adults aged 18 to 60 with facial bone defects or deformities from cystic, tumoral, traumatic, or congenital causes may be eligible. Participants must be willing and able to provide informed consent and able to comply with follow-up visits. Please review eligibility criteria for more details.

Is there any cost to participate in this facial reconstruction clinical trial?

Study-related care, including the implant and all trial visits, is provided at no cost. However, personal travel and other expenses may vary and are not always covered.

Actively Recruiting

Phase Not Applicable

Age: 18Years - 60Years

All Genders

ID07654647

Evaluation of Customized 3D-Printed Titanium Implants for Facial Bone Defect Reconstruction and Aesthetic Correction

Led by Latakia University · Updated on 2026-06-17

Participants Needed

Research Sites

N/A

Total Duration

AI-Summary

What this Trial Is About

This clinical study is investigating the use of patient-specific 3D-printed titanium implants for reconstructing facial defects and improving facial appearance. It includes adults with congenital, traumatic, or post-surgical facial deformities that require reconstructive surgery. The aim is to evaluate the safety, effectiveness, and functional and aesthetic outcomes of these customized implants compared to traditional methods. Participants will undergo detailed preoperative assessments including clinical exams and high-resolution CT scans. Customized implants are designed using computer-aided design CAD and produced with selective laser melting 3D printing technology from medical-grade titanium. Surgical placement follows standard maxillofacial protocols with fixation to bone as needed. Follow-up includes clinical and radiological exams for up to 12 months after surgery. Throughout the study, participants will have assessments to monitor implant fit, stability, complications, facial symmetry, and patient satisfaction. Outcome measures include postoperative complication rates over six months, implant geometric accuracy immediately after printing, and aesthetic improvement scores at three months. Patient satisfaction and total surgery time are also recorded to evaluate the overall success and safety of this reconstructive approach.

CONDITIONS

Brief Title

Clinical Evaluation of Patient-Specific 3D-Printed Titanium Implants for Facial Reconstruction.

Who Can Participate

Age: 18Years - 60Years

All Genders

Eligibility Criteria

You may qualify if you...

Age 18 years or older
Presence of facial bone defects from cystic or tumoral lesions
Acquired or congenital facial deformities with bony defects or asymmetry
Requirement for patient-specific 3D-printed titanium implants for reconstruction
Aesthetic needs including microgenia requiring custom facial implants
Ability to provide written informed consent

You will not qualify if you...

Active pathological lesions at enrollment
Age below 18 years
Radiotherapy within 12 months prior to enrollment
Chronic untreated vitamin D deficiency
Uncontrolled diabetes mellitus
Inability or unwillingness to comply with follow-up requirements

Research Team

Ahmad F Ahmad, Phd

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