Clinical Features and Outcomes of Continuous Blood Purification Versus Non-continuous Blood Purification in Pediatric Patients With Sepsis or Septic Shock

What this Trial Is About

This research aims to explore the effects and timing of continuous blood purification (CBP) in children who have sepsis or septic shock. Sepsis can cause severe immune dysfunction and organ damage, and while CBP may help remove harmful inflammatory factors and support immune balance, the best timing for starting this treatment in children is not yet clear. The study focuses on understanding how early CBP intervention might improve outcomes in pediatric sepsis cases. Participants are divided into two groups: children with sepsis who should receive CBP but did not get it for various reasons, and those who were treated with CBP. CBP is a procedure used to manage fluid overload and organ dysfunction in septic children by removing cytokines and supporting kidney function, especially when other fluid management strategies are insufficient. The study observes these two groups to compare clinical features and outcomes. During the study, researchers will monitor children’s survival rates 28 days after hospital discharge as the main outcome. Secondary measures include creatinine levels in children who do not survive. The study involves regular assessments to track the effects of CBP on organ function and immune response. Participants’ progress is followed from the early treatment phase through discharge and up to 28 days afterward, to gather comprehensive data on treatment impact and prognosis.

Clinical Features and Outcomes of CBP Versus Non-CBP in Septic Children