Actively Recruiting
The Clinical Features and Pregnancy Outcomes of CTD Patients
Led by Qilu Hospital of Shandong University · Updated on 2023-11-18
126
Participants Needed
1
Research Sites
433 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Connective tissue disease (CTD) is a common group of autoimmune diseases, mainly including systemic lupus erythematosus (SLE), antiphospholipid syndrome (APS) , and so on. APS is caused by autoimmune disorders that cause recurrent miscarriage, thrombosis, and thrombocytopenia, and often secondary to connective tissue diseases such as SLE. Undifferentiated connective tissue disease (UCTD) is currently considered to be an independent disease in the classification of CTD. And women of childbearing age who suffer UCTD is more common than that in other definite CTDs. Therefore, the impact of the disease flare and the influence of medicine on pregnancy and lactation are important for these patients who may suffer high-risk of abnormal pregnance.
CONDITIONS
Official Title
The Clinical Features and Pregnancy Outcomes of CTD Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Women aged between 20 and 45 years
- Diagnosed with antiphospholipid syndrome (APS) meeting Sydney classification criteria
- Diagnosed with undifferentiated connective tissue disease (UCTD) with at least one auto-antibody and symptoms suggesting connective tissue disease but not meeting defined CTD criteria
- Willing to participate voluntarily, follow treatment plans, and sign informed consent
You will not qualify if you...
- Known causes of previous pregnancy loss such as chromosome abnormalities in parents or embryo
- Maternal endocrine dysfunctions including corpus luteal insufficiency, polycystic ovarian syndrome, premature ovarian failure, hyperprolactinemia, diabetes, or other hormone axis abnormalities
- Maternal anatomical abnormalities like uterine malformation, Asherman syndrome, cervical incompetence, large uterine fibroids, or vaginal infection
- Severe cardiac, liver, kidney, blood, or endocrine diseases
- Active infections including varicella zoster virus, HIV, HPV, syphilis, or tuberculosis
- Allergy to prednisone, hydroxychloroquine, low-molecular-weight heparin, or aspirin
- History of digestive ulcers or upper gastrointestinal bleeding
- History of cancer
- History of epilepsy or psychotic disorders
- Diagnosis of systemic lupus erythematosus
- Unwillingness or inability to complete pregnancy and follow-up after delivery
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Qilu Hospital
Jinan, Shandong, China, 250012
Actively Recruiting
Research Team
Q
Qiang Shu, Dr.
CONTACT
S
Shuting Li
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here