Impact of Non-invasive Neurally Adjusted Ventilatory Assist on Very Preterm Infants Born Between 27 and 32 Weeks Gestation

What this Trial Is About

This observational study examines the effects of Non-invasive Neurally Adjusted Ventilatory Assist NIV-NAVA on very preterm infants born between 27 weeks 0 days and 31 weeks 6 days of gestation. The research aims to understand how NIV-NAVA influences short-term clinical outcomes and long-term brain development in these infants who need respiratory support shortly after birth. Participants will receive respiratory assistance starting within 48 hours of birth using NIV-NAVA. The respiratory settings will be tailored to each infants condition and may change to other forms of support like nasal continuous airway pressure or high flow nasal cannula, or stop after initial stabilization. If infants develop respiratory distress syndrome, lung surfactant will be given using a less invasive method, and invasive ventilation may be used if necessary. During the study, infants will be closely monitored for respiratory outcomes, including failure rates of NIV-NAVA and duration of ventilation. Researchers will also assess complications like bronchopulmonary dysplasia, brain injuries, and retinopathy. Brain imaging at term-equivalent age and developmental assessments up to 3 years will evaluate neurodevelopmental progress. The study follows infants through their hospital stay up to three months and includes long-term developmental follow-up.

Clinical Impact of Non-invasive Neurally Adjusted Ventilatory Assist in Very Preterm Infants