Observational Study of Three-Vessel Ultrasonic Flow Ratio to Predict Heart Events in Coronary Artery Disease Patients

What this Trial Is About

Researchers are investigating the value of a new ultrasound-based measurement called the three coronary vessel-ultrasonic flow ratio 3V-UFR to predict serious heart problems known as major adverse cardiovascular events MACE in patients with coronary artery disease. This observational study will include at least 494 patients who have significant narrowing 50% or more in all three main coronary arteries. The study aims to understand how well 3V-UFR can help forecast heart events within one year after measurement. Participants who qualify will undergo intravascular ultrasound IVUS, a procedure that captures images inside the coronary arteries. These images will be analyzed by a specialized laboratory to calculate the 3V-UFR. Following this, patients will be monitored for one year to track the occurrence of major heart problems such as cardiac death, heart attacks, or the need for further heart procedures. The study will compare patients with low and high 3V-UFR values to explore its clinical usefulness. During the study, researchers will collect data from the IVUS procedure and track heart-related events at one month, six months, and one year after the procedure. The main outcome measured is the rate of major adverse cardiac events within one year. The study is conducted by the China National Center for Cardiovascular Diseases and focuses on improving care for individuals with coronary artery disease by better assessing their risk of future heart problems.

Clinical Implications of Three-vessel Ultrasonic Flow Ratio Measurement in Patients With Coronary Artery Disease