Study of Acupoint Photodynamic Therapy and Traditional Chinese Medicine to Improve Ovarian Reserve in Women with Diminished Ovarian Reserve

What This Trial Is About

Diminished Ovarian Reserve DOR is a condition characterized by a reduced number of recruitable follicles andor decreased oocyte quality, affecting womens fertility and potentially leading to Premature Ovarian Failure within 1 to 6 years if untreated. This study is a single-center, prospective, randomized, controlled clinical trial investigating the effects of acupoint photodynamic therapy and traditional Chinese medicine on improving ovarian reserve. It aims to clarify treatment roles, explore new metabolic biomarkers, and understand mechanisms behind these therapies in DOR patients. Participants will be randomly assigned to one of three groups acupoint photodynamic therapy combined with Dingkun Dan a traditional Chinese medicine, acupoint photodynamic therapy combined with a placebo, or Dingkun Dan alone. The phototherapy involves daily 20-minute treatments at specific acupoints for five days per cycle, repeated until the next menstruation, while Dingkun Dan or placebo is taken orally twice daily for 21 days each month over three months. During the study, clinical data and serum metabolomics will be collected at baseline and after three months of treatment. Researchers will measure changes in hormone levels such as anti-Mllerian hormone, follicle-stimulating hormone, and antral follicle count, along with biochemical markers, menstrual blood loss, traditional Chinese medicine syndrome scores, and quality of life. The study includes safety monitoring and aims to assess treatment effects through these comprehensive evaluations over the treatment period.

Clinical and Metabolomics Studies on the Improvement of Ovarian Reserve by Acupoint Photodynamic Therapy and Traditional Chinese Medicine Treatment