Study of Genetic Causes and Clinical Features of Primary Aldosteronism in Black Adults and Family Members

What this Trial Is About

Primary aldosteronism PA is a leading cause of secondary high blood pressure, affecting millions of adults. This research focuses on understanding the genetic causes of PA specifically in Black individuals, including those who identify as African American or from the Caribbean diaspora. The study aims to explore how these genetic factors influence aldosterone production and contribute to disease differences observed in this population. It also seeks to find drugs that might help control aldosterone levels effectively. Participants include adults aged 18 to 70 with difficult-to-control blood pressure or diagnosed PA, as well as relatives aged 7 and older of people with PA. The study involves one visit for relatives to provide medical history and blood samples. Those with PA or suspected PA undergo screening visits lasting 1 to 2 hours, followed by a hospital stay of 7 to 10 days for various tests such as blood and urine tests, heart exams, body scans, kidney ultrasound, bone density scans, and hair sample collection. Some invasive tests may be performed with additional consent. Treatment options like surgery or medication may be offered based on results. Participants undergo thorough assessments including medical history review, physical exams, blood and urine analyses, imaging studies, and follow-up visits about a year later to repeat tests. Researchers measure genetic mutations causing PA and their effects on tumor formation and aldosterone production. They also evaluate cardiovascular, kidney, metabolic, bone, and blood clotting impacts of PA and any changes after treatment. The study lasts up to several years, with follow-up visits to monitor outcomes and safety.

Clinical and Molecular Characteristics of Primary Aldosteronism in Blacks