ENDOCHAP Study Clinical and Molecular Research on Endometriosis and Adenomyosis in Women Aged 18 to 42

What this Trial Is About

Researchers are investigating whether endometriosis and adenomyosis are progressive conditions by studying symptoms such as pain, abnormal uterine bleeding, and infertility, as well as lesion size and recurrence. The study also explores molecular aspects like immune interactions, auto-immunity, and the role of microbiota in the diseases development. These benign gynecological disorders affect over 10% of women and often cause significant discomfort and fertility challenges. The study is observational and involves patients consulting for endometriosis, pelvic pain, abnormal uterine bleeding, infertility, or pelvic masses. Participants undergo clinical and molecular evaluations without receiving specific treatments as part of the study. Researchers will use imaging techniques and laboratory tests to monitor anatomical lesions and collect biological samples to analyze molecular markers and microbiota profiles. Participants will have regular gynecological follow-ups over up to 10 years, during which pain, bleeding, fertility outcomes, and lesion changes will be assessed using visual scales and imaging. The study will also track diagnostic delays, clinical correlations, and the impact of different management strategies. Blood tests will analyze antibodies and metabolic pathways, while urine and vaginal samples will characterize microbiota. This long-term monitoring aims to improve understanding and diagnosis of these conditions.

Clinical and Molecular Study of Endometriosis and Adenomyosis