Actively Recruiting
ENDOCHAP Monocentric Cohort: Clinical and Molecular Study of Endometriosis and Adenomyosis
Led by Assistance Publique - Hôpitaux de Paris · Updated on 2025-11-20
5300
Participants Needed
1
Research Sites
26 weeks
Total Duration
On this page
Sponsors
A
Assistance Publique - Hôpitaux de Paris
Lead Sponsor
U
URC-CIC Paris Descartes Necker Cochin
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are investigating whether endometriosis and adenomyosis are progressive conditions by studying symptoms such as pain, abnormal uterine bleeding, and infertility, as well as lesion size and recurrence. The study also explores molecular aspects like immune interactions, auto-immunity, and the role of microbiota in the diseases' development. These benign gynecological disorders affect over 10% of women and often cause significant discomfort and fertility challenges. The study is observational and involves patients consulting for endometriosis, pelvic pain, abnormal uterine bleeding, infertility, or pelvic masses. Participants undergo clinical and molecular evaluations without receiving specific treatments as part of the study. Researchers will use imaging techniques and laboratory tests to monitor anatomical lesions and collect biological samples to analyze molecular markers and microbiota profiles. Participants will have regular gynecological follow-ups over up to 10 years, during which pain, bleeding, fertility outcomes, and lesion changes will be assessed using visual scales and imaging. The study will also track diagnostic delays, clinical correlations, and the impact of different management strategies. Blood tests will analyze antibodies and metabolic pathways, while urine and vaginal samples will characterize microbiota. This long-term monitoring aims to improve understanding and diagnosis of these conditions.
CONDITIONS
Brief Title
Clinical and Molecular Study of Endometriosis and Adenomyosis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Women aged between 18 and 42 years old
- Receiving care for pelvic pain, infertility, or a pelvic mass
- Having a radiological diagnosis made by a referral practitioner and/or operated in the department
You will not qualify if you...
- Women who are HIV-positive, or have hepatitis B or C
- Currently pregnant women
- Women with a cancer diagnosis
- Women refusing to sign consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 10 years
Participants with endometriosis or adenomyosis are observed over time to track symptoms, lesion changes, and clinical outcomes.
Periodic visits during gynecological follow-up
Trial Site Locations
Total: 1 location
1
Port Royal, hospital cochin
Paris, France, 75014
Actively Recruiting
Research Team
C
Charles Chapron, MD
L
Laurence Lecomte, PhD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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