Prevalence, clinical and instrumental features of left bundle branch block-induced cardiomyopathy: the CLIMB registry.
Giuseppe D Sanna, Annamaria De Bellis, Massimo Zecchin...
https://pubmed.ncbi.nlm.nih.gov/34510787Actively Recruiting
Age: 18Years +
All Genders
ID05283603
Observational Registry of Patients with Left Bundle Branch Block
Led by Azienda Ospedaliero Universitaria di Sassari · Updated on 2022-03-17
1000
Participants Needed
1
Research Sites
424 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This research focuses on patients who have left bundle branch block (LBBB) as seen on their ECG. The study aims to explore the clinical, ECG, and imaging features in a large group of these patients. It seeks to find factors that predict when LBBB causes left ventricular systolic dysfunction and to identify outcomes for this population, with the goal of providing data that may influence treatment approaches. Participants will undergo clinical and instrumental follow-up using diagnostic tests such as ECG, echocardiogram, and magnetic resonance imaging. These assessments will help monitor heart function and detect changes over time. The study is observational, meaning it tracks patients without assigning specific treatments. Throughout the study, participants will be regularly evaluated using these tests to monitor left ventricular function and any cardiovascular events like heart failure. The main outcome measured is left ventricular dysfunction over a follow-up period of 20 years. Secondary outcomes include adverse cardiovascular events. This long-term monitoring helps researchers understand the progression and impact of LBBB on heart health.
CONDITIONS
Brief Title
Clinical Observational Registry of Patients With Left Bundle Branch Block
Who Can Participate
Age: 18Years +
All Genders
Eligibility Criteria
You may qualify if you...
- LBBB on ECG
- Age 18 years or older
You will not qualify if you...
- Previous extensive anterior myocardial infarction
- Previous cardiac surgery or transcatheter aortic valve implantation (TAVI)
- Congenital structural heart disease
- Patients implanted with permanent right ventricular stimulation devices and permanent pacing
- Denial to consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Diagnostic Evaluation
Duration - Initial evaluation
Participants undergo clinical and instrumental evaluations including ECG, echocardiogram, and magnetic resonance imaging.
1 visit (in-person)
Long-term Monitoring
Duration - Up to 20 years
Participants are followed over time to monitor left ventricular dysfunction and adverse cardiovascular events.
Periodic visits for follow-up assessments
Trial Site Locations
Total: 1 location
1
Cardiology, AOU Sassari
Sassari, Italy, 07100
Actively Recruiting
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Research Team
G
Giuseppe D Sanna, MD PhD
G
Giuseppe D Sanna, MD PhD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
Frequently Asked Questions
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Published Research Related To This Trial
Left bundle branch block-induced cardiomyopathy: a diagnostic proposal for a poorly explored pathological entity.
Giuseppe D Sanna, Marco Merlo, Eleonora Moccia...
https://pubmed.ncbi.nlm.nih.gov/31186131Transient left bundle branch block and intraventricular dyssynchrony as a cause of reversible left ventricular dysfunction: The "in vivo" documentation of spontaneous electrical remodeling.
Eleonora Moccia, Giuseppe D Sanna, Guido Parodi
https://pubmed.ncbi.nlm.nih.gov/31141243