Observational Study on Skin Changes After Different Dose Treatments with Ablative CO2 and Non-Ablative Fractional Lasers in Healthy Chinese Women Aged 18-60

What this Trial Is About

This clinical observational study focuses on healthy Chinese female volunteers aged 18 to 60 with skin types III to V. It investigates how different intensities of fractional ablative CO2 and non-ablative M22 lasers affect skin damage and repair. The study aims to understand the relationship between laser energy levels and skin responses, providing a foundation for future cosmetic treatment research. Participants receive both types of lasers applied to their inner forearms, with four different energy and density settings per laser on separate small test areas. The ablative CO2 laser creates microscopic thermal injury columns, while the non-ablative 1565 nm laser delivers focused energy below the skin surface without disrupting the outer layer. Each participant acts as their own control with treatments on opposite arms. Throughout the study, skin responses are assessed at multiple time points before treatment, immediately after, and up to 10 days post-exposure. Researchers use clinical evaluations such as swelling and redness, standardized photos, high-frequency ultrasound, and instruments measuring skin color, melanin, hemoglobin, and barrier function. The primary outcome is the change in a composite skin damage score, with additional measurements tracking color and barrier changes to understand acute injury and healing patterns.

Clinical Observational Study on Changes in Skin Physiological Parameters Following Ablative and Non-Ablative Fractional Laser Treatment at Different Doses