Effectiveness of Platelet-Rich Plasma Injection Combined with Rehabilitation for Anterior Cruciate Ligament Injury in Adults Aged 18 to 50

What this Trial Is About

Researchers are evaluating the effectiveness of platelet-rich plasma PRP injections in patients with anterior cruciate ligament ACL injuries. ACL injuries often cause knee instability, pain, and reduced function, and rehabilitation alone may not fully restore recovery for all patients. PRP is made from a small sample of the patients own blood and contains natural growth factors that may help healing and improve knee joint function. Participants will be randomly assigned to one of two groups. The experimental group will receive a single ultrasound-guided PRP injection into the knee joint combined with a standard rehabilitation program that includes physical therapy, functional bracing, and lifestyle changes. The control group will receive the rehabilitation program alone without PRP. Participants will be followed up at 3, 8, and 16 weeks after treatment to assess knee function, pain level, and physical performance using validated outcome measures. The primary outcome is the change in pain intensity measured by the Visual Analog Scale VAS. Secondary outcomes include functional improvement measured by the Knee Injury and Osteoarthritis Outcome Score KOOS. This study aims to provide new information on whether PRP adds benefits to rehabilitation in managing ACL injury.

Clinical Outcome of Intra Articular Injection of Autologous Platelet Rich Plasma in Anterior Cruciate Ligament Injury.