Actively Recruiting
Clinical Outcome of Intra Articular Injection of Autologous Platelet Rich Plasma in Anterior Cruciate Ligament Injury.
Led by Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh · Updated on 2025-09-22
52
Participants Needed
1
Research Sites
21 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating the effectiveness of platelet-rich plasma (PRP) injections in patients with anterior cruciate ligament (ACL) injuries. ACL injuries often cause knee instability, pain, and reduced function, and rehabilitation alone may not fully restore recovery for all patients. PRP is made from a small sample of the patient's own blood and contains natural growth factors that may help healing and improve knee joint function. Participants will be randomly assigned to one of two groups. The experimental group will receive a single ultrasound-guided PRP injection into the knee joint combined with a standard rehabilitation program that includes physical therapy, functional bracing, and lifestyle changes. The control group will receive the rehabilitation program alone without PRP. Participants will be followed up at 3, 8, and 16 weeks after treatment to assess knee function, pain level, and physical performance using validated outcome measures. The primary outcome is the change in pain intensity measured by the Visual Analog Scale (VAS). Secondary outcomes include functional improvement measured by the Knee Injury and Osteoarthritis Outcome Score (KOOS). This study aims to provide new information on whether PRP adds benefits to rehabilitation in managing ACL injury.
CONDITIONS
Brief Title
Clinical Outcome of Intra Articular Injection of Autologous Platelet Rich Plasma in Anterior Cruciate Ligament Injury.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients of both sexes aged 18 to less than 50 years
- History of knee injury within the last 3 months or less
- MRI confirmed ACL injury Grade 1 (low) or Grade 2 (medium)
- ACL injury may be associated with Grade 1 or 2 injury to posterior cruciate ligament (PCL) and/or meniscus
- Hemoglobin greater than 10 gm/dl and platelet count greater than 150,000/microliter before procedure
- Able to understand and give informed consent
You will not qualify if you...
- Received intra articular corticosteroid injections in the injured knee within the last 12 weeks
- Taking systemic steroids
- Age younger than 18 or older than 50 years
- History of platelet disorders or use of anticoagulant or antiplatelet drugs
- Hemoglobin below 10 gm/dl
- Platelet count less than 150,000/microliter
- Complete tear of both ACL bundles on MRI
- Grade 3 or higher PCL or meniscal tear on MRI
- Previous or current ligament reconstruction surgery on the injured knee
- Connective tissue disorders such as Marfan Syndrome or Ehler-Danlos Syndrome
- Inflammatory diseases affecting the knee such as rheumatoid arthritis, spondyloarthritis, gout, or pseudogout
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 16 weeks
Participants receive either an ultrasound guided intraarticular platelet rich plasma (PRP) injection along with conventional conservative methods, or conventional conservative methods alone for anterior cruciate ligament injury.
Visits at baseline, 3 weeks, 8 weeks, and 16 weeks after intervention
Trial Site Locations
Total: 1 location
1
Bangabandhu Sheikh Mujib Medical University
Dhaka, Bangladesh, 1000
Actively Recruiting
Research Team
D
Dr. Isfath Fauzia, MBBS
P
Prof. Dr. Md. Ali Emran, MBBS, FCPS
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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