Clinical Outcomes in Patients With Acute Pulmonary Embolism Undergoing Ultrasound-Assisted Catheter-Directed Thrombolysis.
Dominik F Draxler, Judith Karen Johannes, Masaaki Nakase...
https://pubmed.ncbi.nlm.nih.gov/40281654/Actively Recruiting
Led by Insel Gruppe AG, University Hospital Bern · Updated on 2022-12-15
800
Participants Needed
2
Research Sites
N/A
Total Duration
Researchers are collecting data to study the safety and effectiveness of treatments for patients with pulmonary embolism PE. This study focuses on treatments decided by a multi-disciplinary pulmonary embolism response team PERT and aims to improve treatment decisions, hospital procedures, and methods for PE care. It includes both past patients and those treated after May 2020. The study gathers information on various advanced treatments such as systemic thrombolysis, catheter-directed thrombolysis, and surgical removal of blood clots embolectomy. It includes retrospective data from patients treated between 2001 and April 2020 and prospective data from patients treated after May 2020. The study records treatments and health outcomes related to acute and chronic PE. Participants will have their medical treatments and results reviewed, including any complications during procedures and any recurrence of blood clots up to five years later. Respiratory function and the development of chronic lung-related high blood pressure will also be monitored. The main outcome measured is death occurring within 30 days in the hospital. Participants are followed over time to understand long-term effects and safety.
CONDITIONS
Clinical Outcomes After Acute Pulmonary Embolism
S
Stefan Stortecky, MD
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Insel Gruppe AG, University Hospital Bern
Lead Sponsor
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Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Varies based on treatment modality and clinical course
Participants receive treatment for acute pulmonary embolism, which may include medical therapy, systemic lysis, interventional therapy, or surgical embolectomy based on the pulmonary embolism response team decisions.
Treatment occurs as part of routine healthcare; visit schedules vary accordingly
Duration - Up to 5 years
Participants are monitored for outcomes such as recurrent venous thromboembolism, respiratory and functional status, and development of chronic thromboembolic pulmonary hypertension for up to 5 years after treatment.
Follow-up visits as scheduled for up to 5 years
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
4
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Dominik F Draxler, Judith Karen Johannes, Masaaki Nakase...
https://pubmed.ncbi.nlm.nih.gov/40281654/Insel Gruppe AG, University Hospital Bern
Lead Sponsor