Actively Recruiting
Clinical Outcomes After Non-curative Endoscopic Resection in Early Colorectal Cancer: A Multicenter Study
Led by Nanfang Hospital, Southern Medical University · Updated on 2026-04-21
400
Participants Needed
3
Research Sites
169 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This multicenter study aims to evaluate clinical outcomes and optimize management strategies in patients with early colorectal cancer who undergo non-curative endoscopic resection. Patients with non-curative resection following endoscopic treatment will be enrolled across multiple centers and managed according to real-world clinical decisions, including additional surgery or surveillance. Baseline demographic, endoscopic, and pathological characteristics will be systematically collected. The primary objective is to compare recurrence and survival outcomes between different management strategies. Secondary objectives include identifying prognostic factors associated with recurrence and developing a risk stratification model to guide individualized treatment decisions. All participants will undergo standardized follow-up according to clinical guidelines. This study is expected to provide real-world evidence to refine risk assessment, reduce unnecessary surgery, and improve personalized management for patients with early colorectal cancer after non-curative endoscopic resection.
CONDITIONS
Official Title
Clinical Outcomes After Non-curative Endoscopic Resection in Early Colorectal Cancer: A Multicenter Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 518 years
- Early colorectal cancer confirmed by histopathology
- Underwent endoscopic resection including EMR, ESD, or equivalent techniques
- Pathological diagnosis showing non-curative resection with at least one of: positive margin, submucosal invasion depth >1000 bcm, poor differentiation, lymphovascular invasion, perineural invasion, or high-grade tumor budding
- Availability of complete clinicopathological and follow-up data
- Managed with either additional surgery or surveillance after endoscopic resection
You will not qualify if you...
- Presence of synchronous advanced colorectal cancer or distant metastasis at baseline
- History of other active malignancies
- Diagnosis of inflammatory bowel disease, familial adenomatous polyposis, or other hereditary colorectal cancer syndromes
- Received neoadjuvant therapy before endoscopic resection
- Incomplete pathological data or missing key variables
- Loss to follow-up or follow-up duration less than 6 months
AI-Screening
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Trial Site Locations
Total: 3 locations
1
Nanfang Hospital, Southern Medical University
Guangzhou, Guangdong, China
Actively Recruiting
2
Shenzhen Longgang District People's Hospital
Shenzhen, Guangdong, China
Actively Recruiting
3
The Second Affiliated Hospital of Guangzhou Medical University
Haizhu, Guangzhou, China, Guangdong
Actively Recruiting
Research Team
A
Aimin Li
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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