Actively Recruiting
Clinical and Radiographic Evaluation of Allogenic Dentin Grafts for Alveolar Ridge Preservation: A Prospective Clinical Trial
Led by Jordan University Hospital · Updated on 2025-02-14
10
Participants Needed
1
Research Sites
47 weeks
Total Duration
On this page
Sponsors
J
Jordan University Hospital
Lead Sponsor
H
hanan Jafar
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are evaluating the use of allogenic dentin grafts, derived from human-extracted teeth, for preserving the alveolar ridge after tooth extraction. This trial aims to test two types of grafts: demineralized dentin allografts (DDA) and whole tooth allografts (WTA), as alternatives to traditional autogenous bone grafts. These grafts may offer a sustainable and scalable solution by repurposing extracted teeth, which are usually discarded, and addressing the limitations of autogenous grafts such as donor site issues and limited availability. Participants will receive one of the two allogenic dentin grafts (DDA or WTA) applied to preserve the alveolar ridge following tooth extraction, or no graft in the control group. The study is prospective and non-randomized, focusing on clinical and radiographic evaluation. The grafts are prepared from healthy human donors, and the intervention supports innovative, sustainable dental practices. The trial includes a control group to compare outcomes without grafting. During the study, participants will undergo assessments including cone beam computed tomography (CBCT) scans to measure changes in alveolar ridge width and height from baseline to three months after extraction. Researchers will monitor the biocompatibility and effectiveness of the grafts by comparing these measurements across groups. The total follow-up period for primary outcomes is three months post-extraction, with evaluations of alveolar crest dimensions to support future prosthetic rehabilitation.
CONDITIONS
Brief Title
Clinical and Radiographic Evaluation of Allogenic Dentin Grafts for Alveolar Ridge Preservation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 to 60 years
- Require extraction of at least three teeth for clinical or therapeutic reasons
- In good systemic health without conditions impairing bone healing
- Willing to provide informed consent and participate in follow-ups
- Donors must be students, interns, or residents willing to participate and provide informed consent
- Donors must have no history of systemic diseases such as diabetes, hepatitis, or immune disorders
- Donors must have negative blood screening for HIV, HBV, and HCV
- Donors must be non-smokers or not have smoked within the last six months
You will not qualify if you...
- Systemic conditions affecting oral or overall health such as diabetes, osteoporosis, or immunodeficiency
- Positive blood tests for communicable diseases
- Active oral infections or untreated dental caries
- Pregnant or lactating individuals
- History of radiation therapy to the head and neck region
- Smoking or smoking history within the last six months
- Use of medications affecting bone metabolism (e.g., bisphosphonates, steroids)
- Donors or recipients with substance abuse history within the last six months
- Teeth chosen for extraction must not meet criteria such as severe periodontal disease, irreversible pulpitis, or non-restorable condition impacting oral health or function
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 3 months post-extraction
Participants receive either demineralized dentin allografts (DDA), whole tooth allografts (WTA), or no grafting (control) for alveolar ridge preservation after tooth extraction.
Visits for grafting and follow-up assessments during the 3 months
Trial Site Locations
Total: 1 location
1
Jordan University Hospital
Amman, Jordan, 00962
Actively Recruiting
Research Team
S
Soukaina Ryalat, Prof
H
Hanan Jafar, Dr
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
Similar Trials
Frequently Asked Questions
Have more questions? Get in touch with our team for quick support
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here