Actively Recruiting
Clinical-randomized Trial of Rehabilitation Using Strength and Blood Flow Restriction Training on Muscle Fitness and Recovery After Anterior Cruciate Ligament Reconstruction
Led by University Hospital, Bonn · Updated on 2025-12-08
30
Participants Needed
1
Research Sites
21 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating the effects of strength training combined with blood flow restriction (BFR) on muscle recovery, strength, and knee joint function after anterior cruciate ligament (ACL) reconstruction. The study focuses on outpatient rehabilitation to see if BFR training can improve recovery similarly to previous pre-surgery training benefits. This trial is a clinical-randomized study conducted by the University Hospital, Bonn, aiming to enhance rehabilitation approaches following ACL injury. Participants are randomly assigned to one of two groups: an intervention group receiving strength training with BFR at 60% of individual limb occlusion pressure, and a control group performing similar exercises with a low sham-BFR pressure of 20 mmHg. The training involves approximately 25-minute sessions, five times a week as part of medical training therapy, using resistance exercises based on initial strength measurements. During the study, muscle strength will be measured from before rehabilitation to immediately after three weeks of exercise and up to one year of follow-up. The rehabilitation takes place outpatient, and participants will complete regular exercise therapy units. Researchers will monitor muscle mass regeneration, strength gains, and knee function to assess the intervention's impact on recovery after ACL reconstruction.
CONDITIONS
Brief Title
Clinical-randomized Trial of the Effect of Rehabilitation Therapy Using Strength and Blood Flow Restriction Training on Muscular Fitness and Regeneration After Anterior Cruciate Ligament Reconstruction
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Had ACL reconstruction
- Able to participate in outpatient rehabilitation
You will not qualify if you...
- Have sickle cell anemia
- Have vessel changes in the lower limbs, such as stents or bypasses
- Have inflammation of the lower extremities
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 3 weeks
Participants perform exercise protocols involving resistance training with either blood flow restriction (BFR) or sham-BFR pressure as part of their rehabilitation after ACL reconstruction.
Approximately 5 sessions per week
Duration - Up to 1 year
Participants are monitored for muscle strength improvements and recovery after completing the exercise intervention, up to 1 year post-rehabilitation.
Periodic follow-up visits
Trial Site Locations
Total: 1 location
1
University Hospital Bonn
Bonn, North Rhine-Westphalia, Germany, 53127
Actively Recruiting
Research Team
A
Alexander Franz, Dr. med., B.Sc.
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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