Actively Recruiting
Clinical Registration Study of Haplo-HSCT for Elderly Patients With Acute Leukemia/ Myelodysplastic Syndrome
Led by Peking University People's Hospital · Updated on 2024-09-19
120
Participants Needed
1
Research Sites
182 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study is an open, prospective, single-center, single-arm study expanded based on the study of NCT03412409.The primary objective of this study is to evaluate the transplantation efficacy of the RIC conditioning regimen in elderly patients receiving the transplantation of haploidentical hematopoietic stem cells. Elderly patients are defined as ≥55 years of age; High comorbidity is defined as an HCT-CI score ≥3.Primary endpoint is 1-year LFS. Secondary endpoints are 1-year OS and 1-year TRM, Other indicators to be assessed in this study include acute GVHD, chronic GVHD, CMV activation, EBV activation, engraftment.
CONDITIONS
Official Title
Clinical Registration Study of Haplo-HSCT for Elderly Patients With Acute Leukemia/ Myelodysplastic Syndrome
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients 55 years or older and younger than 70 years with acute leukemia or myelodysplastic syndrome, with or without a high comorbidity score (HCT-CI 653)
- Patients eligible for allogeneic hematopoietic stem cell transplantation
- Patients without HLA matched donors but with available haploidentical donors
- Patients who voluntarily agree to participate and sign the informed consent form
You will not qualify if you...
- Patients with severe infections
- Pregnant or breastfeeding women, or males and females of childbearing potential and their partners who cannot use effective contraception during treatment and for 90 days after
- Patients not eligible for hematopoietic stem cell transplantation
- Patients enrolled in other clinical trials within the past month
- Patients unlikely to complete the study or considered unsuitable by the investigator
- Patients unable to understand or refusing to sign the informed consent form
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Peking University People's Hospital
Beijing, Beijing Municipality, China, 100044
Actively Recruiting
Research Team
S
Sun
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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