Clinical Registration Study of Patients With Intracranial / Carotid Stenosis

What this Trial Is About

Researchers are collecting data from patients aged 40 and older who have significant narrowing (stenosis) of the intracranial or carotid arteries to study how this condition relates to cognitive impairment. The study aims to analyze clinical information, brain imaging, and neuropsychological test results to identify early signs of cognitive decline in these patients. This is an observational registration study supported by the Second Affiliated Hospital, School of Medicine, Zhejiang University. Participants will receive standard medical treatment and may undergo interventional stenting as part of their care, though the study mainly observes and collects data without assigning specific treatments. Data collection includes clinical assessments and various brain imaging techniques. The study follows patients prospectively to monitor changes over time. During the study, participants will undergo cognitive testing using several scales such as the Mini-mental State Examination, Montreal Cognitive Assessment, Colour Trail Test, Hopkins Verbal Learning Test, clock drawing test, Animal Fluency Test, and Olfactory stick test. Researchers will also assess cerebral blood flow, glymphatic function, stroke incidence, and metabolic changes over a two-year follow-up period. Participants will be monitored regularly to track these outcomes and any safety concerns.

Clinical Registration Study of Patients With Intracranial / Carotid Stenosis