Actively Recruiting
Clinical Research on Acute Intermittent Porphyria and the Use of Carbohydrate-Rich Diet as a Treatment
Led by Nordlandssykehuset HF · Updated on 2026-03-27
50
Participants Needed
3
Research Sites
726 weeks
Total Duration
On this page
Sponsors
N
Nordlandssykehuset HF
Lead Sponsor
U
University of Oslo
Collaborating Sponsor
AI-Summary
What this Trial Is About
The main aim of this clinical trial is to learn about the effect of carbohydrate-rich diet as a treatment for AIP (acute intermittent porphyria). Aim: Investigate the diet's impact on tissue and serum glucose, plasma insulin, cytokine levels, amino acids, and gut microbiota in AIP, and their correlation with PBG (Porphobilinogen). Aim: Assess the diet's effect on AIP symptoms and health status in AIP. Aim: Measure the effect of a high-carbohydrate diet on mitochondrial activity in AIP Aim: Map and detect potential mutations in mitochondrial genomic DNA in AIP Aim: Discover new markers in AIP through RNA sequencing and machine learning. Participants will follow two diet plans, a 4-week intervention with 60-65 E% carbohydrates and a 4 week intervention with 40-45 E% carbohydrates.
CONDITIONS
Official Title
Clinical Research on Acute Intermittent Porphyria and the Use of Carbohydrate-Rich Diet as a Treatment
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of AIP
You will not qualify if you...
- Not having diagnosis of AIP
- Undergoing treatment as part of other clinical research on AIP
- Pregnancy
- Diabetes
- Below 18 years of age
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 3 locations
1
Nordland Hospital Trust
Bodø, Nordland, Norway, 8092
Actively Recruiting
2
Studieenheten, Akademiskt Specialistcentrum, Stockholm läns sjukvårdsområde, Region Stockholm
Stockholm, Sweden
Actively Recruiting
3
Norrland University Hospital
Umeå, Sweden
Actively Recruiting
Research Team
E
Elin Storjord, MD PhD
CONTACT
H
Hilde Thunhaug, Nurse
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
TREATMENT
Number of Arms
2
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