Study on Using Electronic Cigarettes and Nicotine Replacement Therapy to Help Adults Who Smoke and Have Obesity Quit Smoking

What this Trial Is About

This research aims to study the effects of alternative nicotine products on smoking habits, weight gain, and related health outcomes in individuals who smoke cigarettes and have obesity. The study focuses on comparing electronic cigarettes EC, nicotine replacement therapy NRT, and no product use among adults with these health conditions. Up to 60 participants will be involved to provide preliminary information on these interventions. Participants will be randomly assigned to one of three groups those who receive electronic cigarettes, those who receive nicotine replacement therapy combining transdermal and oral products, and those in a control group who do not receive any alternative nicotine products. Each participant will use their assigned intervention for 8 weeks. The electronic cigarettes and nicotine replacement therapies are provided with information about their risks compared to smoking. Participants will be assessed at the beginning of the study and then at 1, 2, and 3 months after starting. Researchers will measure smoking behavior, exhaled carbon monoxide levels, and the number of quit attempts at 2 months. They will also track product acceptability and adherence, weight changes, waist size, blood sugar control A1c, inflammation markers, nicotine exposure cotinine, and blood pressure. Monitoring will include remote measurements via a Bluetooth-enabled device to track carbon monoxide and other outcomes during the study period.

Clinical Research Evaluating Smoking Cessation With E-Cigarettes and Nicotine Therapy