Actively Recruiting
Clinical Response and Toxicity of Hypo-fractionated Chemoradiotherapy in Cervix Cancer
Led by Tehran University of Medical Sciences · Updated on 2021-10-12
60
Participants Needed
1
Research Sites
360 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Uterine cervix cancer can be treated definitively with concurrent chemoradiation (external beam radiotherapy and chemotherapy) followed by high dose rate brachytherapy. Treatment duration can be shortened by increasing the dose per fraction of treatment which can reduce costs and patient exposure. The aim of our study is to determine the non-inferiority of hypofractionated radiotherapy compared with conventional treatment.
CONDITIONS
Official Title
Clinical Response and Toxicity of Hypo-fractionated Chemoradiotherapy in Cervix Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Pathology of squamous cell carcinoma, adenocarcinoma, or adenosquamous carcinoma of uterine cervix
- International Federation of Gynecology and Obstetrics (FIGO) stage IB, IIA, IIB, IIIA (with hydronephrosis but without creatinine clearance compromise), or IIIC1 (less than 3 lymph nodes under 3cm and no common iliac chain involvement)
- Patient eligible for definitive chemoradiotherapy followed by brachytherapy
You will not qualify if you...
- Creatinine clearance less than 30 ml/min
- Any histology other than squamous cell carcinoma, adenocarcinoma, or adenosquamous carcinoma
- Need for paraaortic lymph node irradiation
- Inflammatory bowel disease
- Connective tissue disorders
- Previous pelvic radiotherapy
- FIGO stage IA or IV
- Eastern Cooperative Oncology Group (ECOG) performance status above 2
- History of previous hysterectomy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Imam Khomeini Hospital Complex
Tehran, Iran, 1419733141
Actively Recruiting
Research Team
K
Kasra Kolahdouzan, M.D.
CONTACT
E
Ebrahim Esmati, M.D.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here