Test-Retest Reliability of an Adaptive Thermal Pain Calibration Procedure in Healthy Volunteers.
Carolyn Amir, Margaret Rose-McCandlish, Rachel Weger...
https://pubmed.ncbi.nlm.nih.gov/35189353Actively Recruiting
Age: 12Years - 120Years
All Genders
Healthy Volunteers
ID02707029
Clinical and Scientific Assessment of Pain and Painful Disorders
Led by National Center for Complementary and Integrative Health (NCCIH) · Updated on 2026-05-07
10000
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying the experience of pain by including people aged 12 and older who may or may not have pain disorders. The goal is to deeply describe and analyze pain disorders, collect detailed scientific measurements, and identify individuals who might be eligible for other research studies at the National Center for Complementary and Integrative Health (NCCIH). This study is observational, involving up to 10,000 participants of various backgrounds. Participants will have one required visit lasting about 2 hours, which may include medical history, physical exam, questionnaires, blood and urine tests, MRI scans while experiencing different sensations, and various sensory tests involving pictures, sounds, tastes, and smells. Additional monitoring such as electrocardiograms, breathing measurements, and sensors for pulse and sweating will be done. Up to 12 other outpatient visits may occur for further assessments. During the study, participants will be asked questions about their pain and undergo various evaluations including psychological, behavioral, clinical lab tests, and imaging assessments. Researchers will collect data to describe pain disorders and explore potential eligibility for other NIH research. The main outcome is to enable broad and detailed phenotyping of individuals with pain over 36 months, with safety and ongoing monitoring included.
CONDITIONS
Brief Title
Clinical and Scientific Assessment of Pain and Painful Disorders
Who Can Participate
Age: 12Years - 120Years
All Genders
Healthy Volunteers
Eligibility Criteria
You may qualify if you...
- Are 12 years of age or older
You will not qualify if you...
- Have difficulties with communication that make subjective pain assessment impossible or unreliable
- Have acute medical or psychiatric health issues that create additional and substantial adverse risks related to study procedures
- Are participating in other ongoing research protocols that would interfere with this study
- Are employees or staff that work at NCCIH
- Are pregnant
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
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Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person) for informed consent and eligibility assessment
Diagnostic Evaluation
Duration - Initial evaluation with ongoing assessments over several years
Participants undergo a core phenotyping evaluation including a clinical evaluation by a Licensed Independent Practitioner and questionnaires to describe their clinical pain status.
1 baseline visit and additional visits as needed for phenotyping assessments
Long-term Monitoring
Duration - Up to 36 months
Participants may undergo selected scientific measurements and phenotyping assessments over time to enable detailed description of pain disorders and support eligibility for other research protocols.
Visits scheduled over several years depending on phenotyping requirements
Trial Site Locations
Total: 1 location
1
National Institutes of Health Clinical Center
Bethesda, Maryland, United States, 20892
Actively Recruiting
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Research Team
K
Keyonna L Berry
M
Miroslav Backonja, M.D.
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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