Actively Recruiting
A Clinical Study to Assess the Efficacy and Safety of Leriglitazone in Adult Male Subjects With Cerebral Adrenoleukodystrophy
Led by Minoryx Therapeutics, S.L. · Updated on 2025-11-17
40
Participants Needed
13
Research Sites
198 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
A Clinical Study to Assess the Efficacy and Safety of Leriglitazone in Adults Male Subjects with Cerebral Adrenoleukodystrophy.
CONDITIONS
Official Title
A Clinical Study to Assess the Efficacy and Safety of Leriglitazone in Adult Male Subjects With Cerebral Adrenoleukodystrophy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male aged 18 years or older
- Diagnosed with progressive cerebral adrenoleukodystrophy (cALD) shown by gadolinium-enhancing brain lesions
- Not recommended for or unwilling to undergo hematopoietic stem cell transplantation (HSCT)
- Loes score between 0.5 and 12 at screening
- No major functional disability except wheelchair use or total incontinence allowed
- No major cognitive impairment that would prevent participation as assessed by investigator
You will not qualify if you...
- Previous bone marrow transplantation (HSCT) or ex-vivo gene therapy (eli-Cel)
- Known type 1 or type 2 diabetes
- Known allergy or intolerance to pioglitazone or other thiazolidinediones
- Use of honokiol, pioglitazone, or other thiazolidinediones within 3 months before screening
- Current participation in another interventional clinical study or within 1 month prior to screening
- Other medical, neuropsychiatric, or social conditions likely to affect study safety, compliance, or results as judged by investigator
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 13 locations
1
Stanford University Medical Center
Palo Alto, California, United States, 94304-5978
Actively Recruiting
2
Neuro Medicine Hospital / UF Health
Gainesville, Florida, United States, 32608
Withdrawn
3
Kennedy Krieger Institute
Baltimore, Maryland, United States, 21205
Actively Recruiting
4
Massachusetts General Hospital
Boston, Massachusetts, United States, 02114
Actively Recruiting
5
University of Minnesota
Minneota, Minnesota, United States, 55455
Actively Recruiting
6
Health University of Utah
Salt Lake City, Utah, United States, 84112
Withdrawn
7
Hospital Austral
Buenos Aires, Argentina
Actively Recruiting
8
Federal University of Sao Paulo
São Paulo, Brazil
Actively Recruiting
9
ICM La Pitie Salpetriere
Paris, France, 75013
Actively Recruiting
10
Klinik und Poliklinik für Neurologie-Leipzig
Leipzig, Germany, 04103
Actively Recruiting
11
Sir Ganga Ram Hospital
New Delhi, India, 110060
Actively Recruiting
12
Hospital 12 de Octubre
Madrid, Spain, 28041
Actively Recruiting
13
National Hospital for Neurology and Neurosurgery
London, United Kingdom, WC1N 3AX
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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