Actively Recruiting
A Clinical Study of Belzutifan and Zanzalintinib in People With Recurrent Kidney Cancer Following Adjuvant Therapy (MK-6482-033)
Led by Merck Sharp & Dohme LLC · Updated on 2026-05-12
904
Participants Needed
108
Research Sites
326 weeks
Total Duration
On this page
Sponsors
M
Merck Sharp & Dohme LLC
Lead Sponsor
E
Exelixis
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are looking for more ways to treat advanced renal cell carcinoma (RCC) that is recurrent. Researchers want to learn if recurrent advanced renal cell carcinoma (RCC) responds (gets smaller or goes away) after treatment with belzutifan (MK-6482) and zanzalintinib compared to cabozantinib. The goal of this study is to learn if: People who take belzutifan and zanzalintinib live longer overall and without the cancer getting worse than people who take cabozantinib.
CONDITIONS
Official Title
A Clinical Study of Belzutifan and Zanzalintinib in People With Recurrent Kidney Cancer Following Adjuvant Therapy (MK-6482-033)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Histologically confirmed unresectable, advanced renal cell cancer with clear cell component
- Measurable disease per RECIST 1.1 criteria
- Disease recurrence during or within 24 months after adjuvant anti-PD-1/L1 therapy
- No prior systemic therapy for RCC except adjuvant anti-PD-1/L1 therapy
You will not qualify if you...
- Clinically significant cardiovascular disease within 12 months before study
- Deep vein thrombosis within 3 months before randomization unless stable and treated
- Left ventricular ejection fraction 50% or below normal range
- Major surgery within 8 weeks before randomization or incomplete recovery from surgery
- Current pneumonitis or interstitial lung disease
- Symptomatic pleural effusion, ascites, or pericardial fluid requiring recent drainage
- Gastrointestinal disorders with high risk of perforation or fistula
- Serious active nonhealing wound, ulcer, or bone fracture
- Requirement for hemodialysis or peritoneal dialysis
- History of HIV infection
- Hepatitis B or C infection
- Received live or live-attenuated vaccine within 30 days before first study dose
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 108 locations
1
Hospital Aleman ( Site 0204)
CABA, Buenos Aires, Argentina, C1118AAT
Actively Recruiting
2
Hospital Italiano de Buenos Aires. ( Site 0203)
Caba, Buenos Aires, Argentina, C1199ABB
Actively Recruiting
3
Asociación de Beneficencia Hospital Sirio Libanés ( Site 0205)
Caba, Buenos Aires, Argentina, C1419AHN
Actively Recruiting
4
Instituto Alexander Fleming ( Site 0202)
CABA, Buenos Aires, Argentina, C1426ANZ
Actively Recruiting
5
Centro de Educación Médica e Investigaciones clínicas "Dr. Norberto Quirno" (CEMIC) ( Site 0208)
Caba., Buenos Aires F.D., Argentina, C1431FWO
Actively Recruiting
6
Sanatorio Parque ( Site 0201)
Rosario, Santa Fe Province, Argentina, S2000DSV
Actively Recruiting
7
Instituto de Oncología de Rosario ( Site 0209)
Rosario, Santa Fe Province, Argentina, S2000KZE
Actively Recruiting
8
Hospital Privado Universitario de Córdoba ( Site 0207)
Córdoba, Argentina, X5016KEH
Actively Recruiting
9
Macquarie University-MQ Health Clinical Trials Unit ( Site 2100)
Sydney, New South Wales, Australia, 2109
Actively Recruiting
10
Ordensklinikum Linz GmbH Elisabethinen-Urologie ( Site 0600)
Linz, Upper Austria, Austria, 4020
Actively Recruiting
11
Medizinische Universitat Wien ( Site 0601)
Vienna, Austria, 1090
Actively Recruiting
12
Cliniques Universitaires Saint-Luc ( Site 0703)
Brussels, Bruxelles-Capitale, Region de, Belgium, 1200
Actively Recruiting
13
Ziekenhuis Oost-Limburg, Campus St.-Jan ( Site 0701)
Genk, Limburg, Belgium, 3600
Actively Recruiting
14
UZ Gent ( Site 0702)
Ghent, Oost-Vlaanderen, Belgium, 9000
Actively Recruiting
15
UZ Leuven ( Site 0700)
Leuven, Vlaams-Brabant, Belgium, 3000
Actively Recruiting
16
IPC - MT Instituto de Pesquisas Clínicas do Mato Grosso ( Site 0305)
Cuiabá, Mato Grosso, Brazil, 78020-500
Actively Recruiting
17
Liga Norte Riograndense Contra o Câncer ( Site 0307)
Natal, Rio Grande do Norte, Brazil, 59062-000
Actively Recruiting
18
Hospital Moinhos de Vento ( Site 0309)
Porto Alegre, Rio Grande do Sul, Brazil, 90560-032
Actively Recruiting
19
Fundação Faculdade Regional de Medicina de São José do Rio Preto ( Site 0302)
São José do Rio Preto, São Paulo, Brazil, 15090-000
Actively Recruiting
20
Hospital Alemao Oswaldo Cruz ( Site 0311)
São Paulo, São Paulo, Brazil, 01327-001
Actively Recruiting
21
Klinički Bolnički Centar Split ( Site 0802)
Split, Split-Dalmatia County, Croatia, 21000
Actively Recruiting
22
Masarykuv onkologicky ustav ( Site 0903)
Brno, Brno-mesto, Czechia, 656 53
Actively Recruiting
23
Fakultni nemocnice Ostrava ( Site 0904)
Ostrava, Ostrava Mesto, Czechia, 708 52
Actively Recruiting
24
Nemocnice České Budějovice ( Site 0905)
České Budějovice, Czechia, 370 01
Actively Recruiting
25
Fakultni nemocnice Hradec Kralove ( Site 0902)
Hradec Králové, Czechia, 500 05
Actively Recruiting
26
Fakultni nemocnice Olomouc ( Site 0901)
Olomouc, Czechia, 779 00
Actively Recruiting
27
Vseobecna fakultni nemocnice v Praze ( Site 0906)
Prague, Czechia, 128 08
Actively Recruiting
28
Fakultni nemocnice v Motole ( Site 0900)
Prague, Czechia, 150 06
Actively Recruiting
29
Herlev Hospital ( Site 1002)
Herlev, Capital Region, Denmark, 2730
Actively Recruiting
30
Aarhus University Hospital Skejby ( Site 1001)
Aarhus, Central Jutland, Denmark, 8200
Actively Recruiting
31
Odense Universitetshospital ( Site 1000)
Odense, Region Syddanmark, Denmark, 9000
Actively Recruiting
32
CHU de Bordeaux Hop St ANDRE ( Site 1115)
Bordeaux, Gironde, France, 33075
Actively Recruiting
33
Hôpital Foch ( Site 1118)
Suresnes, Hauts-de-Seine, France, 92150
Actively Recruiting
34
Centre de Cancérologie du Grand Montpellier ( Site 1112)
Montpellier, Herault, France, 34070
Actively Recruiting
35
CHU GRENOBLE ALPES ( Site 1101)
La Tronche, Isere, France, 38700
Actively Recruiting
36
Centre d'Oncologie de Gentilly ( Site 1117)
Nancy, Lorraine, France, 54100
Actively Recruiting
37
Centre Hospitalier Universitaire d'Angers-Urology ( Site 1104)
Angers, Pays de la Loire Region, France, 49933
Actively Recruiting
38
Centre Hospitalier de la Côte Basque ( Site 1113)
Bayonne, Pyrenees-Atlantiques, France, 64109
Actively Recruiting
39
centre hospitalier lyon sud ( Site 1102)
Pierre-Bénite, Rhone, France, 69310
Actively Recruiting
40
CHU de Rouen ( Site 1108)
Rouen, Seine-Maritime, France, 76031
Actively Recruiting
41
HENRI MONDOR HOSPITAL ( Site 1116)
Créteil, Val-de-Marne, France, 94010
Actively Recruiting
42
CHD Vendee ( Site 1103)
La Roche-sur-Yon, Vendee, France, 85000
Actively Recruiting
43
Klinikum Stuttgart - Katharinenhospital ( Site 1201)
Stuttgart, Baden-Wurttemberg, Germany, 70174
Actively Recruiting
44
UniversitaetsklInikum Tuebingen ( Site 1207)
Tübingen, Baden-Wurttemberg, Germany, 72076
Actively Recruiting
45
Universitätsmedizin Göttingen - Georg-August-Universität ( Site 1211)
Göttingen, Lower Saxony, Germany, 37075
Actively Recruiting
46
Helios Kliniken Schwerin GmbH ( Site 1206)
Schwerin, Mecklenburg-Vorpommern, Germany, 19055
Actively Recruiting
47
Marienhospital Herne ( Site 1215)
Herne, North Rhine-Westphalia, Germany, 44625
Actively Recruiting
48
Universitaetsklinikum Muenster ( Site 1202)
Münster, North Rhine-Westphalia, Germany, 70174
Actively Recruiting
49
Universitaetsklinikum Carl Gustav Carus Dresden ( Site 1213)
Dresden, Saxony, Germany, 01307
Actively Recruiting
50
HELIOS Klinikum Erfurt ( Site 1208)
Erfurt, Thuringia, Germany, 99089
Actively Recruiting
51
Universitätsklinikum Jena ( Site 1204)
Jena, Thuringia, Germany, 07747
Actively Recruiting
52
Charité Universitaetsmedizin Berlin - Campus Mitte ( Site 1203)
Berlin, Germany, 10117
Actively Recruiting
53
Universitaetsklinikum Hamburg-Eppendorf ( Site 1214)
Hamburg, Germany, 20246
Actively Recruiting
54
Alexandra General Hospital of Athens ( Site 1300)
Athens, Attica, Greece, 115 28
Actively Recruiting
55
Metropolitan Hospital ( Site 1302)
Athens, Attica, Greece, 185 47
Actively Recruiting
56
University General Hospital ''Attikon'' - General Hospital of West Attica "H AGIA VARVARA" ( Site 1301)
Chaïdári, Attica, Greece, 124 62
Actively Recruiting
57
Prince of Wales Hospital ( Site 2200)
Hong Kong, Hong Kong
Actively Recruiting
58
Queen Mary Hospital ( Site 2201)
Hong Kong, Hong Kong
Actively Recruiting
59
Cork University Hospital ( Site 1501)
Cork, Ireland, T12 YK23
Actively Recruiting
60
Tallaght University Hospital ( Site 1500)
Dublin, Ireland, D24 NR0A
Actively Recruiting
61
Azienda Ospedaliera Di Rilievo Nazionale A. Cardarelli ( Site 1609)
Naples, Campania, Italy, 80131
Actively Recruiting
62
Istituto Nazionale Tumori Regina Elena ( Site 1611)
Rome, Lazio, Italy, 00144
Actively Recruiting
63
Fondazione IRCCS Istituto Nazionale dei Tumori ( Site 1600)
Milan, Milano, Italy, 20133
Actively Recruiting
64
Istituto Clinico Humanitas ( Site 1613)
Rozzano, Milano, Italy, 20089
Actively Recruiting
65
Azienda Ospedaliera S. Luigi Gonzaga ( Site 1607)
Orbassano, Piedmont, Italy, 10043
Actively Recruiting
66
Fondazione Policlinico Universitario Agostino Gemelli IRCCS - Università Cattolica del Sacro Cuore ( Site 1601)
Rome, Roma, Italy, 00618
Actively Recruiting
67
Azienda Ospedaliera Universitaria Careggi ( Site 1608)
Florence, Tuscany, Italy, 50134
Actively Recruiting
68
Casa di Cura Dott. Pederzoli - UO Oncologia ( Site 1610)
Peschiera del Garda, Veneto, Italy, 37019
Actively Recruiting
69
Azienda USL 8 di Arezzo ( Site 1605)
Arezzo, Italy, 52100
Actively Recruiting
70
A.O.U.C. Policlinico di Bari ( Site 1602)
Bari, Italy, 70124
Actively Recruiting
71
IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico di Sant'Orsola ( Site 1604)
Bologna, Italy, 40138
Actively Recruiting
72
Ospedale San Martino ( Site 1606)
Genova, Italy, 16132
Actively Recruiting
73
CIO - Centro de Inmuno-Oncología de Occidente ( Site 0503)
Guadalajara, Jalisco, Mexico, 44630
Actively Recruiting
74
I CAN ONCOLOGY CENTER S.A. DE C.V. ( Site 0507)
Monterrey, Nuevo León, Mexico, 64710
Actively Recruiting
75
Centro de Investigacion Clinica de Oaxaca ( Site 0502)
Oaxaca City, Oaxaca, Mexico, 68020
Actively Recruiting
76
Higiea Oncologia ( Site 0504)
Mexico City, Mexico, 11810
Actively Recruiting
77
Clinica Integral Internacional de Oncología ( Site 0506)
Puebla City, Mexico, 72530
Actively Recruiting
78
AIDPORT Sp. z o.o. ( Site 1716)
Skórzewo, Greater Poland Voivodeship, Poland, 60-185
Actively Recruiting
79
Centrum Onkologii im. Prof. Franciszka Lukaszczyka ( Site 1707)
Bydgoszcz, Kuyavian-Pomeranian Voivodeship, Poland, 85-796
Actively Recruiting
80
Pratia MCM Krakow ( Site 1713)
Krakow, Lesser Poland Voivodeship, Poland, 30-727
Actively Recruiting
81
Szpital Specjalistyczny im. Ludwika Rydygiera w Krakowie ( Site 1703)
Krakow, Lesser Poland Voivodeship, Poland, 31-826
Actively Recruiting
82
Mazowiecki Szpital Wojewódzki w Siedlcach-Siedleckie Centrum Onkologii ( Site 1702)
Siedlce, Masovian Voivodeship, Poland, 08-110
Actively Recruiting
83
MTZ Clinical Research Powered by Pratia ( Site 1705)
Warsaw, Masovian Voivodeship, Poland, 02-172
Actively Recruiting
84
Wojewodzki Szpital im. Sw. Ojca Pio w Przemyslu ( Site 1710)
Przemyśl, Podkarpackie Voivodeship, Poland, 37-700
Actively Recruiting
85
Szpital Wojewodzki im. Mikolaja Kopernika w Koszalinie ( Site 1701)
Koszalin, West Pomeranian Voivodeship, Poland, 75-581
Actively Recruiting
86
National University Hospital ( Site 2400)
Singapore, Central Singapore, Singapore, 119074
Actively Recruiting
87
National Cancer Centre Singapore ( Site 2401)
Singapore, Central Singapore, Singapore, 168583
Actively Recruiting
88
Chonnam National University Hwasun Hospital ( Site 2505)
Hwasun-gun, Jeonranamdo, South Korea, 58128
Actively Recruiting
89
Seoul National University Bundang Hospital ( Site 2504)
Seongnam, Kyonggi-do, South Korea, 13620
Actively Recruiting
90
Chungnam National University Hospital ( Site 2506)
Taejŏn, Taejon-Kwangyokshi, South Korea, 35015
Actively Recruiting
91
Severance Hospital, Yonsei University Health System ( Site 2503)
Seoul, South Korea, 03722
Actively Recruiting
92
Asan Medical Center ( Site 2501)
Seoul, South Korea, 05505
Actively Recruiting
93
Samsung Medical Center ( Site 2502)
Seoul, South Korea, 06351
Actively Recruiting
94
Institut Català d'Oncologia - L'Hospitalet ( Site 1805)
L'Hospitalet de Llobregat, Barcelona, Spain, 08908
Actively Recruiting
95
Hospital Universitario Marqués de Valdecilla ( Site 1807)
Santander, Cantabria, Spain, 39008
Actively Recruiting
96
Institut Català d'Oncologia (ICO) - Girona ( Site 1806)
Girona, Gerona, Spain, 17007
Actively Recruiting
97
Hospital Universitario Ramón y Cajal ( Site 1801)
Madrid, Madrid, Comunidad de, Spain, 28034
Actively Recruiting
98
Fundación Instituto Valenciano de Oncología ( Site 1808)
Valencia, Valenciana, Comunitat, Spain, 46009
Actively Recruiting
99
Hospital Universitari Vall d'Hebron ( Site 1804)
Barcelona, Spain, 08035
Actively Recruiting
100
Hospital Clinic de Barcelona ( Site 1810)
Barcelona, Spain, 08036
Actively Recruiting
101
Hospital Universitario Reina Sofia ( Site 1809)
Córdoba, Spain, 14004
Actively Recruiting
102
Hospital Clinico San Carlos ( Site 1802)
Madrid, Spain, 28040
Actively Recruiting
103
Hospital Universitario Fundacion Jimenez Diaz ( Site 1803)
Madrid, Spain, 28040
Actively Recruiting
104
Hospital Universitario 12 de Octubre ( Site 1800)
Madrid, Spain, 28041
Actively Recruiting
105
China Medical University Hospital ( Site 2603)
Taichung, Taiwan, 40447
Actively Recruiting
106
Taichung Veterans General Hospital ( Site 2602)
Taichung, Taiwan, 40705
Actively Recruiting
107
Taipei Veterans General Hospital ( Site 2600)
Taipei, Taiwan, 11217
Actively Recruiting
108
Chang Gung Memorial Hospital - Linkou Branch ( Site 2604)
Taoyuan, Taiwan, 333
Actively Recruiting
Research Team
T
Toll Free Number
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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