Actively Recruiting
Clinical Study of Carbon Ion Radiotherapy for High-grade Glioma
Led by Gansu Wuwei Tumor Hospital · Updated on 2025-02-18
23
Participants Needed
1
Research Sites
151 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The objective is to use the advantages of heavy ion physical dosimetry and biology to improve the tumor control rate and long-term survival rate of high-grade glioma, reduce the occurrence of brain tissue radiation damage caused by increasing prescription dose, and provide new treatment suggestions for glioma radiotherapy.
CONDITIONS
Official Title
Clinical Study of Carbon Ion Radiotherapy for High-grade Glioma
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 14 years to 80 years
- Diagnosis of high-grade glioma based on 2021 WHO CNS tumor classification, including IDH wild-type glioma and IDH mutant Grade II and III gliomas
- Single or two intracranial lesions covered by the same radiotherapy plan
- No distant or intraspinal spread or metastasis
- No tumor ablation or interventional therapy within 4 weeks prior to radiotherapy
- Surgical wound fully healed
- Ability to undergo MRI and enhanced CT without metal artifacts
- No history of other malignant tumors except cured skin cancer and stage 0 cervical cancer
- Normal liver, kidney, and bone marrow function within specified lab values
- Good physical condition with ECOG 0 to 2 and no severe comorbidities affecting radiotherapy
- Adequate major organ function
- Predicted survival of at least 6 months after treatment
- Signed informed consent by patient or legal representative
You will not qualify if you...
- Glioma diagnosis not confirmed by pathology
- Unable to lie still for 30 minutes
- Recurrent tumors receiving secondary treatment
- Presence of distant metastases or more than two intracranial lesions
- Prior head radiotherapy with photon, proton, or carbon ions
- Intracranial radioactive particle implantation with metal implants affecting radiation dose
- Unable to undergo MRI due to claustrophobia or incompatible implants
- Pacemakers or metal implants that interfere with radiation or device function
- Organ dose limits cannot meet preset safe thresholds
- Pregnancy or lactation
- Significant weight loss over 20% in past 6 months
- AIDS or active syphilis
- Serious uncontrolled systemic diseases or substance abuse
- Poor compliance or inability to complete treatment and follow-up
- Other malignant neoplasms except cured skin cancer and stage 0 cervical cancer
- Contraindications to radiotherapy
- Participation in other drug trials within 30 days
- Limited legal capacity
- Medical history that could interfere with trial or increase risk
- Investigator judgment deeming trial participation inappropriate or unsafe
- Inability or unwillingness to understand or consent to treatment
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Heavy Ion Radiotherapy Department
Wuwei, Gansu, China, 733000
Actively Recruiting
Research Team
X
Xiaojun Li
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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