Actively Recruiting
Clinical Study of Carbon Ion Radiotherapy for Pancreatic Cancer.
Led by Gansu Wuwei Tumor Hospital · Updated on 2025-03-25
62
Participants Needed
1
Research Sites
200 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The objective is to evaluate the efficacy and safety of carbon ion radiotherapy (CIRT) combined with nituzumab and gemcitabine in the treatment of locally advanced and metastatic pancreatic cancer.
CONDITIONS
Official Title
Clinical Study of Carbon Ion Radiotherapy for Pancreatic Cancer.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 to 80 years
- Locally advanced or metastatic pancreatic adenocarcinoma confirmed by histopathology or cytology (stage III-IV)
- At least one measurable lesion according to RECIST 1.1 criteria
- Suitable for one cycle of gemcitabine combined with nituzumab
- No history of other malignant tumors except cured skin cancer and stage 0 cervical cancer
- Normal liver, kidney, and bone marrow function within specified laboratory limits
- Good physical condition with ECOG performance status 0 to 2 and no severe cardiopulmonary complications
- Adequate major organ functions
- Predicted survival of at least 3 months after treatment
- Signed informed consent before radiotherapy
You will not qualify if you...
- Use of monoclonal antibodies, EGFR-TKI therapy, anti-angiogenic drugs, or immunosuppressants within 6 months
- Uncontrolled pleural effusion, pericardial effusion, ascites, gastrointestinal bleeding, or high bleeding risk within 14 days prior to admission
- Participation in other interventional clinical trials within 30 days prior to screening
- Organ dose limits cannot be met safely
- Chronic steroid hormone therapy longer than 6 months or prednisone dose over 10 mg/day
- Allergy to study drugs or their components
- Pregnancy or breastfeeding
- AIDS or active syphilis
- Serious uncontrolled comorbidities or substance abuse preventing trial participation
- Poor compliance or inability to complete treatment or follow-up
- Contraindications to radiotherapy
- Limited legal capacity
- Any medical history or condition judged by the investigator to interfere with trial results or increase patient risk
- Inability or unwillingness to understand or consent to treatment protocol
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Heavy Ion Radiotherapy Department
Wuwei, Gansu, China, 733000
Actively Recruiting
Research Team
X
Xiaojun Li
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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