Actively Recruiting
Clinical Study to Compare Efficacy and Safety of AVT29 and Eylea HD in Participants With Diabetic Macular Edema
Led by Alvotech Swiss AG · Updated on 2026-04-30
256
Participants Needed
1
Research Sites
88 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a Randomized, Double-masked, Parallel-group, Multicenter Clinical Study to Evaluate the Efficacy and Safety of AVT29 Compared with Eylea HD in Participants with Diabetic Macular Edema.
CONDITIONS
Official Title
Clinical Study to Compare Efficacy and Safety of AVT29 and Eylea HD in Participants With Diabetic Macular Edema
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Participant is 18 years old or older at the time of signing the informed consent form
- Participant is willing and able to comply with all study procedures and likely to complete the study
- Participant has a diagnosis of diabetic macular edema secondary to diabetes mellitus with central involvement in the study eye
- Participant has a best-corrected visual acuity ETDRS letter score between 73 and 34 letters inclusive (20/40 to 20/200 Snellen equivalent) in the study eye at screening and on Day 1 prior to randomization
- Participant's vision decrease is primarily due to diabetic macular edema in the study eye
You will not qualify if you...
- Previous treatment with anti-VEGF therapy
- History or concurrent disease other than diabetic macular edema that could compromise visual acuity
- Any condition that may interfere with full participation in the study or pose significant risk, as judged by the investigator
- Participants judged unsuitable for participation due to medical, psychiatric conditions, or potential noncompliance by the investigator
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Site 3004
Budapest, Hungary
Actively Recruiting
Research Team
S
Silvia Cirillo
CONTACT
R
Riken Soni
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here