Actively Recruiting
Clinical Study of Desuzumab in the Treatment of Knee Osteoarthritis
Led by Union Hospital, Tongji Medical College, Huazhong University of Science and Technology · Updated on 2025-04-09
30
Participants Needed
1
Research Sites
230 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
As an activator of inhibiting nuclear factor kB receptor, denosumab affects osteoclast differentiation and development by inhibiting OPG/RANKL-RANK bone regulatory axis pathway. Therefore, denosumab is widely used in the treatment of bone diseases such as osteoporosis. Osteoporosis is closely related to knee osteoarthritis. RANKL-RANK pathway also plays a key role in the pathogenesis of knee osteoarthritis. Therefore, the investigators propose the hypothesis that denosumab can effectively treat knee osteoarthritis.
CONDITIONS
Official Title
Clinical Study of Desuzumab in the Treatment of Knee Osteoarthritis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients diagnosed with knee osteoarthritis meeting the diagnostic criteria for arthritis
- No drug contraindications
- Aged between 45 and 75 years
- Willing to follow research procedures and cooperate throughout the study
- Understands the treatment process
- Able to provide informed consent
- Has not recently taken medications affecting the study observation
- Meets all inclusion criteria to participate in the study
You will not qualify if you...
- Presence of mental illness
- Diagnosis of malignant tumors
- Having other infectious diseases
- Having metabolic bone disease, diabetes, or hyperthyroidism
- Unable to actively cooperate in treatment
- Having low calcium levels (hypocalcemia)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Wuhan Union Hospital
Wuhan, Hubei, China, 430000
Actively Recruiting
Research Team
T
Tian Hongtao, Doctorate
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
15
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here