What this Trial Is About

Atrial fibrillation (AF) is a common and serious irregular heart rhythm that raises the risk of death, stroke, heart failure, and cognitive problems, especially for patients who also have obstructive sleep apnea (OSA). Catheter ablation is a treatment used to correct AF, but its success is lower in patients with OSA. Continuous positive airway pressure (CPAP) is a treatment for OSA that helps improve breathing during sleep. While some studies suggest CPAP may lower AF recurrence after ablation, its effect remains unclear, prompting further research. This study compares two groups of patients with AF and moderate to severe OSA who all first undergo catheter ablation. One group receives CPAP treatment at home, using the device for at least 4 hours per night on at least 5 days each week, while the other group receives conventional treatment without CPAP. Both groups are monitored to evaluate how often AF returns after the ablation. Participants will be followed for up to 12 months after ablation, with assessments of AF recurrence and AF burden at 3, 6, 9, and 12 months. All patients undergo sleep pressure titration before starting CPAP to determine the correct pressure settings. The study tracks patient adherence to CPAP therapy and collects data to help guide future treatments for AF patients with OSA.

Clinical Study on the Effect of CPAP on AF Recurrence After Catheter Ablation in Patients with AF and OSA