Actively Recruiting
A Clinical Study of Enlicitide in Participants With High Cholesterol (MK-0616-037)
Led by Merck Sharp & Dohme LLC · Updated on 2026-04-28
975
Participants Needed
89
Research Sites
67 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers designed a study medicine called enlicitide to lower low-density lipoprotein cholesterol (LDL-C). In this study, researchers want to learn about giving enlicitide with another medicine called rosuvastatin. Rosuvastatin is a standard (usual) treatment to lower LDL-C. The goal of this study is to learn if enlicitide given with rosuvastatin works better than placebo on lowering LDL-C in a person's blood. A placebo looks like the study medicine but has no study medicine in it. Using a placebo helps researchers better understand the effects of a study medicine.
CONDITIONS
Official Title
A Clinical Study of Enlicitide in Participants With High Cholesterol (MK-0616-037)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 to 64 years
- Have either not received lipid-lowering therapy recently or have not received certain lipid-lowering therapies within a specified time before the study
You will not qualify if you...
- History of homozygous, compound heterozygous, or double heterozygous familial hypercholesterolemia
- Heart failure hospitalization within 3 months before screening
- Unwillingness to take statins, history of statin-associated muscle symptoms, or intolerance to one or more statins
- History of myopathy, myositis, rhabdomyolysis, unexplained muscle pain, muscular or neuromuscular disease, neuropathy, fibromyalgia, chronic pain, or hereditary muscular disorders in self or family
- Active or chronic liver or bile duct disease
- Known HIV infection
- Undergoing or planning LDL-C apheresis within 3 months before screening
- Use of medications that interact with rosuvastatin within 5 half-lives before screening or planning to start such medications
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 89 locations
1
Central Research Associates ( Site 0009)
Birmingham, Alabama, United States, 35205
Actively Recruiting
2
G&L Research ( Site 0024)
Foley, Alabama, United States, 36535
Actively Recruiting
3
Synexus Clinical Research US, Inc. - Phoenix Central ( Site 0030)
Phoenix, Arizona, United States, 85020
Actively Recruiting
4
Alliance for Multispecialty Research LLC ( Site 0049)
Tempe, Arizona, United States, 85281
Actively Recruiting
5
Chemidox Clinical Trials ( Site 0008)
Lancaster, California, United States, 93534
Actively Recruiting
6
Clinical Trials Research ( Site 0036)
Sacramento, California, United States, 95821
Actively Recruiting
7
Legacy Clinical Trials ( Site 0044)
Colorado Springs, Colorado, United States, 80909
Actively Recruiting
8
Alliance for Multispecialty Research, LLC ( Site 0040)
Fort Myers, Florida, United States, 33912
Actively Recruiting
9
Soffer Health Institute ( Site 0046)
Hollywood, Florida, United States, 33020
Actively Recruiting
10
East Coast Institute for Research ( Site 0041)
Lake City, Florida, United States, 32055
Actively Recruiting
11
Inpatient Research Clinic ( Site 0017)
Miami Lakes, Florida, United States, 33014
Active, Not Recruiting
12
Clinical Research Trials of Florida ( Site 0001)
Tampa, Florida, United States, 33607
Actively Recruiting
13
Clinical Site Partners LLC, dba CSP Orlando ( Site 0014)
Winter Park, Florida, United States, 32789
Actively Recruiting
14
Trialmed ( Site 0026)
Chicago, Illinois, United States, 60602
Actively Recruiting
15
Great Lakes Clinical Trials - Ravenswood ( Site 0018)
Chicago, Illinois, United States, 60640
Actively Recruiting
16
Midwest Institute For Clinical Research ( Site 0033)
Indianapolis, Indiana, United States, 46260-5310
Actively Recruiting
17
Alliance for Multispecialty Research, LLC ( Site 0048)
Newton, Kansas, United States, 67114
Actively Recruiting
18
Cotton O'Neil Clinical Research Center ( Site 0006)
Topeka, Kansas, United States, 66606
Actively Recruiting
19
Monroe Biomedical Research ( Site 0004)
Louisville, Kentucky, United States, 40213
Actively Recruiting
20
Jubilee Clinical Research ( Site 0031)
Las Vegas, Nevada, United States, 89106
Actively Recruiting
21
Cardiovascular Associates of the Delaware Valley ( Site 0035)
Elmer, New Jersey, United States, 08318
Actively Recruiting
22
New Mexico Clinical Research & Osteoporosis Center, Inc. ( Site 0027)
Albuquerque, New Mexico, United States, 87106-4725
Actively Recruiting
23
Alliance for Multispecialty Research, LLC - Norman ( Site 0043)
Norman, Oklahoma, United States, 73069
Actively Recruiting
24
Cardiology Consultants of Philadelphia Yardley ( Site 0016)
Yardley, Pennsylvania, United States, 19067
Actively Recruiting
25
Provecta Research Network LLC ( Site 0022)
Houston, Texas, United States, 77027
Actively Recruiting
26
Permian Research Foundation ( Site 0005)
Odessa, Texas, United States, 79761
Actively Recruiting
27
LinQ Research ( Site 0025)
Pearland, Texas, United States, 77584
Actively Recruiting
28
Clinical Trials of Texas, Inc. ( Site 0010)
San Antonio, Texas, United States, 78229
Actively Recruiting
29
Stone Oak, LLC dba Discovery Clinical Trials (DCT) ( Site 0021)
San Antonio, Texas, United States, 78258
Actively Recruiting
30
LinQ Research - Tomball ( Site 0047)
Tomball, Texas, United States, 77375
Actively Recruiting
31
Conquest Research ( Site 0045)
Arlington, Virginia, United States, 22205
Actively Recruiting
32
Manassas Clinical Research Center ( Site 0002)
Manassas, Virginia, United States, 20110
Actively Recruiting
33
Health Research of Hampton Roads, Inc. ( Site 0013)
Newport News, Virginia, United States, 23606
Actively Recruiting
34
National Clinical Research, Inc ( Site 0028)
Richmond, Virginia, United States, 23294
Actively Recruiting
35
Rainier Clinical Research ( Site 0023)
Renton, Washington, United States, 98057
Actively Recruiting
36
CEMEDIC ( Site 0201)
CABA, Buenos Aires, Argentina, C1407GTL
Actively Recruiting
37
Instituto de Investigaciones Clínicas Mar del Plata ( Site 0202)
Mar del Plata, Buenos Aires, Argentina, B7600FZO
Actively Recruiting
38
CIPREC-CIPREC Sede Arenales ( Site 0200)
Buenos Aires, Buenos Aires F.D., Argentina, C1061AAS
Actively Recruiting
39
Fundacion Estudios Clinicos ( Site 0203)
Rosario, Santa Fe Province, Argentina, S2000CVD
Actively Recruiting
40
Instituto de Investigaciones Clinicas Rosario ( Site 0204)
Rosario, Santa Fe Province, Argentina, S2000CVD
Actively Recruiting
41
Centro Medico Dra. Laura Maffei- Investigacion Clinica Aplicada ( Site 0206)
CABA, Argentina, C1425AGC
Actively Recruiting
42
Instituto de Cardiología "Juana F. Cabral"-Cardiología ( Site 0205)
Corrientes, Argentina, W3400AMZ
Actively Recruiting
43
Australian Clinical Research Network ( Site 0900)
Maroubra, New South Wales, Australia, 2035
Actively Recruiting
44
Momentum Darlinghurst ( Site 0906)
Sydney, New South Wales, Australia, 2010
Actively Recruiting
45
Momentum Clinical Research Taringa ( Site 0907)
Taringa, Queensland, Australia, 4068
Actively Recruiting
46
Fusion Clinical Research ( Site 0901)
Norwood, South Australia, Australia, 5067
Actively Recruiting
47
Emeritus Research ( Site 0904)
Camberwell, Victoria, Australia, 3124
Actively Recruiting
48
Baker - HeartWest ( Site 0902)
Hoppers Crossing, Victoria, Australia, 3029
Actively Recruiting
49
Centro de Pesquisas em Diabetes e Doenças Endócrino-Metabólicas ( Site 0306)
Fortaleza, Ceará, Brazil, 60430-350
Actively Recruiting
50
Centro de Pesquisa Clinica do Coracao ( Site 0303)
Aracaju, Sergipe, Brazil, 49055-530
Actively Recruiting
51
Hospital Universitário São Francisco de Assis - Bragança Paulista ( Site 0305)
Bragança Paulista, São Paulo, Brazil, 12916-542
Actively Recruiting
52
Fundação Faculdade Regional de Medicina de São José do Rio Preto ( Site 0309)
São José do Rio Preto, São Paulo, Brazil, 15090-000
Actively Recruiting
53
IBPClin - Instituto Brasil de Pesquisa Clínica ( Site 0302)
Rio de Janeiro, Brazil, 20241-180
Actively Recruiting
54
G A Research Associates ( Site 0102)
Moncton, New Brunswick, Canada, E1G 1A7
Actively Recruiting
55
Milestone Research Inc. ( Site 0111)
London, Ontario, Canada, N5W 6A2
Actively Recruiting
56
North York Diagnostic and Cardiac Centre ( Site 0110)
North York, Ontario, Canada, M6B 3H7
Actively Recruiting
57
Care Access - Thunder Bay ( Site 0130)
Thunder Bay, Ontario, Canada, P7B 7C7
Actively Recruiting
58
Centricity Research Mirabel Multispecialty ( Site 0107)
Mirabel, Quebec, Canada, J7J 2K8
Actively Recruiting
59
Institut de Cardiologie de Montreal ( Site 0109)
Montreal, Quebec, Canada, H1T 1C8
Actively Recruiting
60
Recherche Clinique Sigma Inc ( Site 0108)
Québec, Quebec, Canada, G1G 5X1
Actively Recruiting
61
Lausmed Egészségügyi Szolgáltató ( Site 1105)
Baja, Bács-Kiskun county, Hungary, 6500
Actively Recruiting
62
Borbánya Praxis ( Site 1103)
Nyíregyháza, Szabolcs-Szatmár-Bereg, Hungary, 4405
Active, Not Recruiting
63
DRC Gyógyszervizsgáló Központ ( Site 1109)
Balatonfüred, Veszprém megye, Hungary, 8230
Actively Recruiting
64
Debreceni Egyetem Klinikai Kozpont-Belgyógyászati Klinika (Anyagcsere Tanszék) ( Site 1102)
Debrecen, Hungary, 4032
Actively Recruiting
65
Barzilai Medical Center ( Site 0504)
Ashkelon, Israel, 7830604
Actively Recruiting
66
Linn Medical Center ( Site 0503)
Haifa, Israel, 3100000
Actively Recruiting
67
Rambam Health Care Campus ( Site 0500)
Haifa, Israel, 3109601
Actively Recruiting
68
Meir Medical Center. ( Site 0501)
Kfar Saba, Israel, 4428164
Actively Recruiting
69
Clalit Health Services - Sakhnin Community Clinic ( Site 0502)
Sakhnin, Israel, 3081000
Actively Recruiting
70
Pacific Clinical Research Network - Rotorua ( Site 1001)
Rotorua, Bay of Plenty, New Zealand, 3010
Actively Recruiting
71
Pacific Clinical Research Network - Forte ( Site 1004)
Christchurch, Canterbury, New Zealand, 8013
Actively Recruiting
72
Pacific Clinical Research Network - Tasman ( Site 1003)
Nelson, Tasman District, New Zealand, 7011
Actively Recruiting
73
Lakeland Clinical Trials Waikato ( Site 1000)
Nawton, Waikato Region, New Zealand, 3200
Actively Recruiting
74
Lakeland Clinical Trials Wellington ( Site 1002)
Upper Hutt, Wellington Region, New Zealand, 5018
Actively Recruiting
75
Centro de Salud Concepcion Arenal ( Site 0603)
Santiago de Compostela, Galicia, Spain, 15701
Actively Recruiting
76
EAP Sardenya ( Site 0601)
Barcelona, Spain, 08025
Actively Recruiting
77
EBA Centelles ( Site 0600)
Barcelona, Spain, 08540
Actively Recruiting
78
Hacettepe Universite Hastaneleri ( Site 0700)
Sıhhiye, Ankara, Turkey (Türkiye), 06230
Actively Recruiting
79
Ufuk University Dr.Ridvan Ege Hospital ( Site 0709)
Ankara, Turkey (Türkiye), 06520
Actively Recruiting
80
Eskisehir Osmangazi University ( Site 0705)
Eskişehir, Turkey (Türkiye), 26480
Actively Recruiting
81
Istanbul Universitesi - Cerrahpasa Kardiyoloji Enstitusu ( Site 0703)
Istanbul, Turkey (Türkiye), 34080
Actively Recruiting
82
Ege Universitesi Hastanesi ( Site 0708)
Izmir, Turkey (Türkiye), 35080
Actively Recruiting
83
Erciyes Universitesi Tıp Fakultesi Hastaneleri ( Site 0701)
Kayseri, Turkey (Türkiye), 38030
Actively Recruiting
84
İnönü Üniversitesi Turgut Özal Tıp Merkezi ( Site 0702)
Malatya, Turkey (Türkiye), 44280
Actively Recruiting
85
Velocity Clinical Research, Bristol ( Site 0803)
Bristol, Bristol, City of, United Kingdom, BS8 2RA
Actively Recruiting
86
West Walk Surgery ( Site 0801)
Yate, Gloucestershire, United Kingdom, BS37 4AX
Actively Recruiting
87
Velocity Clinical Research Havering ( Site 0804)
London, Havering, United Kingdom, RM1 3PJ
Actively Recruiting
88
William Harvey Heart Centre ( Site 0800)
London, London, City of, United Kingdom, EC1M 6BQ
Actively Recruiting
89
Lakeside Surgery ( Site 0802)
Corby, Northamptonshire, United Kingdom, NN17 2UR
Actively Recruiting
Research Team
T
Toll Free Number
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
FACTORIAL
Primary Purpose
TREATMENT
Number of Arms
4
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