Actively Recruiting
A Clinical Study to Evaluate the Effectiveness of an Experimental Toothpaste in Improving Gum Health and Reducing Plaque Accumulation
Led by HALEON · Updated on 2025-12-19
300
Participants Needed
1
Research Sites
32 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The aim of this 24-week clinical study is to evaluate the ability of an experimental dentifrice containing 0.454 percent (%) weight by weight (w/w) Stannous fluoride (SnF2); to improve gingival health, plaque reduction and prevention of plaque accumulation compared with a regular fluoride dentifrice (negative control) in participants with mild to moderate gingivitis.
CONDITIONS
Official Title
A Clinical Study to Evaluate the Effectiveness of an Experimental Toothpaste in Improving Gum Health and Reducing Plaque Accumulation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Signed informed consent before any study assessments
- Male or female participants aged 18 years or older
- Willing and able to follow scheduled visits, treatment plans, and study procedures
- In good general and mental health with no significant medical or oral conditions affecting safety or study outcomes
You will not qualify if you...
- Employees of the study site or the sponsor and their immediate family members
- Participation in other investigational studies within 30 days before or during this study
- Acute or chronic medical or psychiatric conditions that increase risk or affect study results
- Pregnancy or intention to become pregnant during the study, or breastfeeding
- Known allergy or intolerance to study materials
- Unwillingness or inability to follow lifestyle requirements
- Current smokers or recent ex-smokers (within 6 months) including vaping, or use of smokeless tobacco
- Diagnosis of dry mouth or medications causing dry mouth
- Medical conditions or bleeding disorders affecting gum bleeding or study safety
- Recent history of alcohol or substance abuse within the last year
- Severe oral conditions that may affect oral health or study outcomes
- Oral piercings or features interfering with toothbrush use
- Active dental caries, dentures, or recent orthodontic treatment or devices affecting study procedures
- Numerous poor dental restorations or dental conditions compromising oral health or study outcomes
- Dental cleaning or teeth bleaching within 12 weeks before screening
- High levels of external stains or calculus affecting plaque assessments
- Previous enrollment in this study
- Any other condition deemed inappropriate for study participation by the investigator
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Salus Research, Inc.
Fort Wayne, Indiana, United States, 46825
Actively Recruiting
Research Team
H
Haleon Response Center
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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