Actively Recruiting
Clinical Study to Evaluate Efficacy of Cabergoline to Coasting in Reducing the Incidence of Ovarian Hyperstimulation Syndrome
Led by Tanta University · Updated on 2026-03-13
150
Participants Needed
1
Research Sites
72 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Ovarian hyperstimulation syndrome (OHSS) is a serious iatrogenic complication of controlled ovarian stimulation of gonadotrophin-Stimulated ovarian cycles. It is theorized to manifest systemically as a result of vasoactive mediators like vascular endothelium growth factor (VEGF) being released from hyperstimulated ovaries. As a result, capillary permeability is increased which causes the extravasation of fluid from the intravascular compartment into the third space. The haemoconcentration which ensues results in complications such as hypercoagulability and reduced end organ perfusion.
CONDITIONS
Official Title
Clinical Study to Evaluate Efficacy of Cabergoline to Coasting in Reducing the Incidence of Ovarian Hyperstimulation Syndrome
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 18 and 38 years
- Body mass index less than 30 kg/m2
- Use of a long luteal protocol for ovarian stimulation
- Day 2 FSH less than 10 mIU/L and estradiol less than 50 pg/ml
- High risk of OHSS defined as more than 20 follicles larger than 12 mm and/or estradiol levels above 3000 pg/ml when leading follicle is larger than 15 mm
You will not qualify if you...
- Presence of chronic medical diseases including liver cell failure, renal failure, uncontrolled hypertension, uncontrolled diabetes mellitus, or class 3 or 4 heart disease according to the New York Heart Association classification
- Allergy to cabergoline
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Mostafa Bahaa
Damietta, New Damietta, Egypt, 34518
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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