Actively Recruiting
A Clinical Study on Exercise Guided by CPET to Reduce the Risk of Metabolic Cardiovascular Diseases（C-MET Trial）
Led by Peking University Third Hospital · Updated on 2024-07-30
220
Participants Needed
1
Research Sites
84 weeks
Total Duration
On this page
Sponsors
P
Peking University Third Hospital
Lead Sponsor
B
Beijing Chao Yang Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
The main purpose of this study is to validate the effect of an individualized exercise prescription developed based on cardiopulmonary exercise testing (CPET) in subjects with metabolic syndrome. This study aims to assess the improvement in cardiovascular metabolic risk associated with the personalized exercise regimen,known as individualized HIIT.
CONDITIONS
Official Title
A Clinical Study on Exercise Guided by CPET to Reduce the Risk of Metabolic Cardiovascular Diseases（C-MET Trial）
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 30 and 65 years for both males and females
- Sedentary lifestyle: sitting more than 6 hours daily for the past 6 months
- Insufficient physical activity: less than 150 minutes of moderate or less than 75 minutes of high-intensity activity per week
- Diagnosis of metabolic syndrome by 2009 AHA/IDF criteria with at least three of the following: abdominal obesity (waist circumference 90 cm for males, 80 cm for females), fasting blood glucose 5.6 mmol/L, blood pressure 130/85 mm Hg, fasting triglycerides 1.7 mmol/L, reduced HDL cholesterol (male <1.0 mmol/L, female <1.3 mmol/L)
- Triglycerides below 500 mg/dl (5.6 mmol/L)
- Fasting blood glucose below 7 mmol/L
- Baseline blood pressure below 140/90 mm Hg
- Willingness to improve health through exercise
You will not qualify if you...
- Contraindications to cardiopulmonary exercise testing (CPET)
- Positive CPET exercise electrocardiogram results
- Elevated LDL cholesterol requiring statin therapy
- Current treatment with antihypertensive, antidiabetic, lipid-lowering, or antiarrhythmic drugs
- Use of dietary supplements or over-the-counter products affecting study results (e.g., fish oil, red yeast rice, weight loss drugs, meal replacements, probiotics, berberine)
- Mental disorders
- Conditions impairing exercise or recent lower limb injuries within 6 months
- Pregnancy, breastfeeding, or plans to become pregnant soon
- Other conditions judged unsuitable by researchers
- Refusal to sign informed consent form
AI-Screening
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Trial Site Locations
Total: 1 location
1
Peking University Third Hospital
Beijing, Beijing Municipality, China, 100191
Actively Recruiting
Research Team
J
Jun Gao, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
HEALTH_SERVICES_RESEARCH
Number of Arms
2
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