Actively Recruiting
A Clinical Study of Fundus OCTA for the Identification of CMD
Led by Peking University First Hospital · Updated on 2025-08-12
400
Participants Needed
1
Research Sites
148 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Coronary microvascular dysfunction (CMD) carries an increased risk of adverse cardiovascular clinical outcomes. The association between fundus microcirculation changes and coronary microcirculation is not well understood. Optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA) is a new type of optical diagnostic imaging technology for non-invasive detection, which can perform multi-dimensional quantitative assessment of fundus microcirculation. In this study, investigators intend to use the coronary angiography-derived index of microvascular resistance (caIMR) to screen patients with CMD, explore the relationship between relevant parameters based on OCT and OCTA measurements and caIMR, and evaluate the feasibility and clinical value of non-invasive identification of CMD through fundus OCT and OCTA.
CONDITIONS
Official Title
A Clinical Study of Fundus OCTA for the Identification of CMD
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients who underwent coronary angiography in the Department of Cardiology, Peking University First Hospital
- Complete baseline clinical information
- Coronary angiography results showing coronary stenosis less than 50%
- Older than 18 years
- Signed informed consent
You will not qualify if you...
- Present serious fundus disease
- Severe cataract or other eye diseases affecting imaging quality
- Target coronary vessels provide collateral circulation for chronic complete occlusive lesions
- Poor filling, overlapping, or severe distortion of target coronary angiography agent preventing lesion location exposure
- Poor quality coronary angiography images that cannot be identified
- Active bleeding state
- Severe renal insufficiency, contrast agent allergy, or inability to perform coronary angiography
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Peking university first hospital
Beijing, Beijing Municipality, China, 10034
Actively Recruiting
Research Team
B
Bo Zheng, Dr
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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