Actively Recruiting
A Clinical Study of Fundus Optical Coherence Tomography Angiography for the Identification of Coronary Microvascular Diseases
Led by Peking University First Hospital · Updated on 2025-08-12
400
Participants Needed
1
Research Sites
2 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This research aims to explore the relationship between changes in the small blood vessels in the eye and coronary microvascular dysfunction (CMD), a condition linked to angina and heart ischemia without blocked large coronary arteries. CMD increases the risk of serious heart problems, but current tests to assess it can be costly, involve radiation, or take a long time. The study will use a new optical imaging technology called optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA) to non-invasively examine the eye's microcirculation and compare it with coronary microcirculation measured by a coronary angiography-derived index of microvascular resistance (caIMR).
CONDITIONS
Brief Title
A Clinical Study of Fundus OCTA for the Identification of CMD
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients who underwent coronary angiography in the Department of Cardiology, Peking University First Hospital
- Complete baseline clinical information
- Coronary angiography results showing less than 50% coronary artery stenosis
- Age 18 years or older
- Signed informed consent to participate
You will not qualify if you...
- Serious fundus (eye) disease
- Severe cataract or other eye diseases affecting image quality
- Target coronary vessels providing collateral circulation for chronic complete occlusive lesions
- Poorly filled, overlapped, or severely distorted coronary angiography images that do not fully show lesion location
- Coronary angiography images of poor quality that cannot be identified
- Active bleeding state
- Severe kidney failure, allergy to contrast agents, or inability to undergo coronary angiography
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Approximately 14 months
Participants undergo coronary angiography and fundus OCT and OCTA imaging to assess coronary microvascular disease and fundus microcirculation.
1 visit (in-person)
Duration - Up to 15 months
Participants are followed to evaluate the diagnostic accuracy of fundus OCT and OCTA for coronary microvascular disease.
Follow-up visits as needed
Trial Site Locations
Total: 1 location
1
Peking university first hospital
Beijing, Beijing Municipality, China, 10034
Actively Recruiting
Research Team
B
Bo Zheng, Dr
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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