Actively Recruiting
A Retrospective and Prospective Observational Study of Hyperthyroidism in Children
Led by Shengjing Hospital · Updated on 2024-08-27
1000
Participants Needed
1
Research Sites
52 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This research aims to study children with hyperthyroidism by collecting information on their diagnosis, treatment, and long-term follow-up. The study focuses on understanding the clinical features, treatment effects, side effects, remission, and relapse of hyperthyroidism in children. It also investigates factors that predict the response to antithyroid drug treatment and explores risks linked to adverse reactions from these drugs. The study observes children treated with methimazole (MMI), a drug given initially at 0.2-0.8 mg per kilogram per day. The dose is gradually reduced and adjusted based on thyroid hormone test results to maintain normal thyroid function. This observational study includes both retrospective and prospective data collection without any intervention. Participants will be monitored over time to assess remission, defined as normal thyroid function without methimazole for at least 12 months, and adverse effects such as neutropenia, liver dysfunction, rash, and muscle or joint pain. Relapse after stopping methimazole will also be tracked. The study involves clinical evaluations, biochemical tests, and long-term follow-up lasting up to 10 years to understand treatment outcomes and safety.
CONDITIONS
Brief Title
A Clinical Study of Hyperthyroidism in Children
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 14 years old or younger
- Initial diagnosis of hyperthyroidism
You will not qualify if you...
- Hyperthyroidism previously treated with medication at other hospitals
- History of autoimmune hepatitis, viral hepatitis, hematological diseases, bone marrow or liver transplantation
- Patients with incomplete clinical data
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 10 years
Participants receive methimazole medication with dosing adjusted based on thyroid hormone levels during follow-up visits.
Regular follow-up visits for dose adjustment and monitoring
Duration - Up to 10 years
Participants are monitored for remission, relapse, and adverse effects after methimazole treatment.
Periodic visits for clinical and biochemical assessments
Trial Site Locations
Total: 1 location
1
Shengjing Hospital of China Medical University
Shenyang, Liaoning, China, 110004
Actively Recruiting
Research Team
S
Shi Tang, Doctor
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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