Actively Recruiting
Clinical Study of Intrastromal Anti-VEGF Injection for Corneal Neovascularization.
Led by Second Affiliated Hospital, School of Medicine, Zhejiang University · Updated on 2026-01-09
100
Participants Needed
1
Research Sites
52 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Corneal stromal injection is an emerging local drug delivery method, characterized by strong targeting, high drug concentration, and prolonged duration of action. It has been preliminarily applied in the treatment of fungal keratitis and neurotrophic corneal diseases. This study aims to investigate the safety and efficacy of anti-VEGF drugs delivered via corneal stromal injection in neovascularization caused by HSK (Herpes Simplex Keratitis). The study has clear medical significance and technical feasibility, and it is expected to promote innovation in the treatment paradigm for corneal neovascularization.
CONDITIONS
Official Title
Clinical Study of Intrastromal Anti-VEGF Injection for Corneal Neovascularization.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of Herpes Simplex Virus keratitis with corneal neovascularization
- Adults aged 18 years or older
- No previous anti-VEGF treatments or corneal surgeries
- Ability to understand and sign informed consent
- Willingness to participate in the study and follow all treatment and follow-up plans
- Other criteria as determined by the investigator
You will not qualify if you...
- Risk of corneal perforation
- Severe dry eye syndrome
- Systemic diseases affecting nervous or immune systems, such as diabetes, rheumatoid arthritis, or autoimmune diseases
- Recent use of systemic immunosuppressive agents
- Inability to adhere to treatment or follow-up schedules
- Pregnancy or breastfeeding
- Allergy to the study medication or related components
- Other reasons deemed unsuitable by the investigator
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
1 Xihu Avenue, Shangcheng District,Hangzhou, Zhejiang,China,Hangzhou, Zhejiang Completed
Hangzhou, Zhejiang, China
Actively Recruiting
Research Team
X
Xiuming Jin
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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