Actively Recruiting
Clinical Study of Ivonescimab for First-line Treatment of Metastatic NSCLC Patients With High PD-L1
Led by Summit Therapeutics · Updated on 2026-02-24
780
Participants Needed
202
Research Sites
222 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Clinical study of ivonescimab for first-line treatment of metastatic NSCLC patients with high PD-L1. Evaluating overall survival and progression free survival.
CONDITIONS
Official Title
Clinical Study of Ivonescimab for First-line Treatment of Metastatic NSCLC Patients With High PD-L1
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 65 18 years old at the time of enrollment
- Eastern Cooperative Oncology Group (ECOG) performance status score of 0 - 1
- Expected life expectancy 65 3 months
- Metastatic (Stage IV) NSCLC
- Histologically or cytologically confirmed squamous or non-squamous NSCLC
- Tumor demonstrates high PD-L1 expression (TPS >50%) based on a 22C3 immunohistochemistry (IHC) clinical assay approved/cleared by local health authorities
- At least one measurable noncerebral lesion according to RECIST 1.1
- No prior systemic treatment for metastatic NSCLC.
You will not qualify if you...
- Presence of small cell lung carcinoma or evidence of it requiring first-line approved therapies
- Prior therapy for metastatic NSCLC
- Concurrent enrollment in another interventional clinical study
- Known actionable genomic alterations requiring first-line approved therapies
- Symptomatic CNS metastases, CNS metastasis 65 1.5 cm, recent CNS radiation within 7 days, potential need for CNS radiation in first cycle, or leptomeningeal disease
- Other prior malignancy unless curative therapy with no recurrence for 3 years
- Active autoimmune or lung disease requiring systemic therapy
- Pre-existing peripheral neuropathy 65 Grade 2 by CTCAE version 5
- Severe infection within 4 weeks prior to randomization
- Major surgery or serious trauma within 4 weeks prior to randomization
- History of noninfectious pneumonia requiring systemic corticosteroids or current interstitial lung disease
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 202 locations
1
Clinical Study Site
Chandler, Arizona, United States, 85224
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2
Clinical Study Site
Phoenix, Arizona, United States, 85006
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3
Clinical Study Site
Hot Springs, Arkansas, United States, 71913
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4
Clinical Study Site
Cerritos, California, United States, 90703
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5
Clinical Study Site
Glendale, California, United States, 91204
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6
Clinical Study Site
Irvine, California, United States, 92612
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7
Clinical Study Site
Los Angeles, California, United States, 90067
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8
Clinical Study Site
Mountain View, California, United States, 94040
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9
Clinical Study Site
Murrieta, California, United States, 92562
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10
Clinical Study Site
Newport Beach, California, United States, 92663
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11
Clinical Study Site
Roseville, California, United States, 95661
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12
Clinical Study Site
Sacramento, California, United States, 95816
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13
Clinical Study Site
San Diego, California, United States, 92123
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14
Clinical Study Site
San Francisco, California, United States, 94115
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15
Clinical Study Site
Santa Ana, California, United States, 92705
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16
Clinical Study Site
Whittier, California, United States, 90602
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17
Clinical Study Site
Aurora, Colorado, United States, 80045
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18
Clinical Study Site
Grand Junction, Colorado, United States, 81505
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19
Clinical Study Site
Greeley, Colorado, United States, 80631
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20
Clinical Study Site
Lone Tree, Colorado, United States, 80124
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21
Clinical Study Site
Loveland, Colorado, United States, 80538
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22
Clinical Study Site
Fort Lauderdale, Florida, United States, 33317
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23
Clinical Study Site
Hialeah, Florida, United States, 33013
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24
Clinical Study Site
Jacksonville, Florida, United States, 32256
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25
Clinical Study Site
Miami, Florida, United States, 33155
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26
Clinical Study Site
North Venice, Florida, United States, 34275
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27
Clinical Study Site
Orlando, Florida, United States, 32822
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28
Clinical Study Site
Pensacola, Florida, United States, 32504
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29
Clinical Study Site
Plantation, Florida, United States, 33322
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30
Clinical Study Site
Plantation, Florida, United States, 33323
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31
Clinical Study Site
Tallahassee, Florida, United States, 32308
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32
Clinical Study Site
Tamarac, Florida, United States, 33321
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33
Clinical Study Site
West Palm Beach, Florida, United States, 33401
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34
Clinical Study Site
Atlanta, Georgia, United States, 30318
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35
Clinical Study Site
Macon, Georgia, United States, 30318
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36
Clinical Study Site
Macon, Georgia, United States, 31210
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37
Clinical Study Site
Carterville, Illinois, United States, 62918
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38
Clinical Study Site
Indianapolis, Indiana, United States, 46237
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39
Clinical Study Site
Waukee, Iowa, United States, 50263
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40
Clinical Study Site
Lexington, Kentucky, United States, 40503
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41
Clinical Study Site
Covington, Louisiana, United States, 70433
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42
Clinical Study Site
Baltimore, Maryland, United States, 21229
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43
Clinical Study Site
Boston, Massachusetts, United States, 02215
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44
Clinical Study Site
Milton, Massachusetts, United States, 02186
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45
Clinical Study Site
Worcester, Massachusetts, United States, 01655
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46
Clinical Study Sites
Detroit, Michigan, United States, 48202
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47
Clinical Study Site
Detroit, Michigan, United States, 48202
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48
Clinical Study Site
Lansing, Michigan, United States, 48910
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49
Clinical Study Site
Minneapolis, Minnesota, United States, 55455
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50
Clinical Study Site
Saint Louis Park, Minnesota, United States, 55426
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51
Clinical Study Site
Saint Paul, Minnesota, United States, 55101
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52
Clinical Study Site
Hattiesburg, Mississippi, United States, 39401
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53
Clinical Study Site
Kansas City, Missouri, United States, 64132
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54
Clinical Study Site
St Louis, Missouri, United States, 63128
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55
Clinical Study Site
Lebanon, New Hampshire, United States, 03756
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56
Clinical Study Site
Basking Ridge, New Jersey, United States, 07920
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57
Clinical Study Site
Middletown, New Jersey, United States, 07748
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58
Clinical Study Site
Montvale, New Jersey, United States, 07645
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59
Clinical Study Site
Mullica Hill, New Jersey, United States, 08062
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60
Clinical Study Site
New Brunswick, New Jersey, United States, 08901
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61
Clinical Study Site
Glen Falls, New York, United States, 12801
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62
Clinical Study Site
Harrison, New York, United States, 10604
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63
Clinical Study Site
New York, New York, United States, 10065
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64
Clinical Study Site
Syracuse, New York, United States, 13210
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65
Clinical Study Site
Uniondale, New York, United States, 11553
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66
Clinical Study Site
Chapel Hill, North Carolina, United States, 27592
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67
Clinical Study Site
Columbus, Ohio, United States, 43219
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68
Clinical Study Sites
Lebanon, Ohio, United States, 45036
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69
Clinical Study Site
Oklahoma City, Oklahoma, United States, 73102
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70
Clinical Study Site
Eugene, Oregon, United States, 97401
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71
Clinical Study Site
Portland, Oregon, United States, 97239
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72
Clinical Study Site
Philadelphia, Pennsylvania, United States, 19111
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73
Clinical Study Site
Pittsburgh, Pennsylvania, United States, 15232
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74
Clinical Study Site
Nashville, Tennessee, United States, 37235
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75
Clinical Study Site
Abilene, Texas, United States, 79601
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76
Clinical Study Site
Austin, Texas, United States, 78745
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77
Clinical Study Site
Dallas, Texas, United States, 75246
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78
Clinical Study Site
Forth Worth, Texas, United States, 76104
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79
Clinical Study Site
Houston, Texas, United States, 77030
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80
Clinical Study Site
Tyler, Texas, United States, 75708
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81
Clinical Study Site
Webster, Texas, United States, 77598
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82
Clinical Study Site
Salt Lake City, Utah, United States, 84106
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83
Clinical Study Site
Blacksburg, Virginia, United States, 24060
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84
Clinical Study Site
Charlottesville, Virginia, United States, 22908
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85
Clinical Study Site
Fairfax, Virginia, United States, 22031
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86
Clinical Study Site
Richmond, Virginia, United States, 23229
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87
Clinical Study Site
Richmond, Virginia, United States, 23298
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88
Clinical Study Site
Seattle, Washington, United States, 98109
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89
Clinical Study Site
Vancouver, Washington, United States, 98684
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90
Clinical Study Site
Edmonton, Alberta, Canada, T6G 1Z2
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91
Clinical Study Site
London, Ontario, Canada, N6A 5W9
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92
Clinical Study Site
Montreal, Quebec, Canada, H3T 1E2
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93
Clinical Study Site
Montreal, Canada, H3T 1E2
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94
Clinical Study Site
Fuzhou, Fujian, China
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95
Clinical Study Site
Guangzhou, Guangdong, China
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96
Clinical Study Site
Haikou, Hainan, China
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97
Clinical Study Site
Harbin, Heilongjiang, China, 150081
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98
Clinical Site Study
Changzhou, Jiangsu, China
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99
Clinical Study Site
Ganzhou, Jiangxi, China
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100
Clinical Study Site
Nanchang, Jiangxi, China
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101
Clinical Study Site
Tai’an, Shandong, China
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102
Clinical Study Site
Weifang, Shandong, China
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103
Clinical Study Site
Shanghai, Shanghai Municipality, China
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104
Clinical Study Site
Kunming, Yunnan, China
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105
Clinical Study Site
Hangzhou, Zhejiang, China
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106
Clinical Study Site
Taizhou, Zhejiang, China
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107
Clinical Site Study
Wenzhou, Zhejiang, China
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108
Clinical Study Site
Changchun, China
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109
Clinical Study Site
Guangzhou, China
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110
Clinical Study Site
Xi'an, China
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111
Clinical Study Site
Nantes, Pays de Loire, France, 44277
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112
Clinical Study Site
Brest, France, 29200
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113
Clinical Study Site
Créteil, France, 94010
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114
Clinical Study Site
Lyon, France, 69008
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115
Clinical Study Site
Marseille, France, 13000
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116
Clinical Study Site
Paris, France, 75020
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117
Clinical Study Site
Rennes, France, 35033
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118
Clinical Study Site
Villejuif, France, 94800
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119
Clinical Study Site
Chemnitz, Germany, 91116
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120
Clinical Study Site
Gauting, Germany, 82131
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121
Clinical Study Site
Giesen, Germany, 35392
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122
Clinical Study Site
Karlsruhe, Germany, 76137
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123
Clinical Study Site
Minden, Germany, 32429
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124
Clinical Study Site
Moers, Germany, 47441
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125
Clinical Study Site
Möser, Germany, 47441
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126
Clinical Study Site
Athens, Greece, 15562
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127
Clinical Study Site
Rio, Greece, 26504
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128
Clinical Study Site
Thessaloniki, Greece, 546 22
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129
Clinical Study Site
Budapest, Hungary, 01121
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130
Clinical Study Site
Kecskemét, Hungary, 6000
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131
Clinical Study Site
Bari, Italy, 70124
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132
Clinical Study Site
Milan, Italy, 20037
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133
Clinical Study Site
Milan, Italy, 20141
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134
Clinical Study Site
Orbassano, Italy, 10043
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135
Clinical Study Site
Parma, Italy, 43126
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136
Clinical Study Site
Roma, Italy, 00144
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137
Clinical Study Site
Asahikawa, Hokkaido, Japan, 078-8510
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138
Clinical Study Site
Nishinomiya, Hyōgo, Japan, 663-8501
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139
Clinical Study Site
Matsusaka, Mie-ken, Japan, 515-8544
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140
Clinical Study Site
Sendai, Miyagi, Japan, 980-8574
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141
Clinical Study Site
Omura-shi, Nagasaki, Japan, 856-8562
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142
Clinical Study Site
Hirakata, Osaka, Japan, 573-1191
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143
Clinical Study Site
Osaka, Osaka, Japan, 541-8567
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144
Clinical Study Site
Hidaka, Saitama, Japan, 350-1298
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145
Clinical Study Site
Shimotsuke, Tochigi, Japan, 329-0498
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146
Clinical Study Site
Bunkyō-Ku, Tokyo, Japan, 113-8677
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147
Clinical Study Site
Koto-Ku, Tokyo, Japan, 135-8550
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148
Clinical Study Site
Wakayama, Wakayama, Japan, 641-8510
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149
Clinical Study Site
Kanazawa, Japan, 920-8641
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150
Clinical Study Site
Kumamoto, Japan, 861-4193
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151
Clinical Study Site
Kurume, Japan, 830-0011
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152
Clinical Study Site
Nagoya, Japan, 460-0001
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153
Clinical Study Site
Okayama, Japan, 700-8558
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154
Clinical Study Site
Sakai, Japan, 591-8555
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155
Clinical Study Site
Tokyo, Japan, 104-0045
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156
Clinical Study Site
Guadalajara, Mexico, 44670
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157
Clinical Study Site
Mexico City, Mexico, 06700
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158
Clinical Study Site
Monterrey, Mexico, 64710
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159
Clinical Study Site
Veracruz, Mexico, 91900
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160
Clinical Study Site
Gdansk, Poland, 80214
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161
Clinical Study Site
Lodz, Poland, 93338
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162
Clinical Study Site
Lublin, Poland, 20064
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163
Clinical Study Site
Poznan, Poland, 60-693
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164
Clinical Study Site
Skorzewo, Poland, 60185
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165
Clinical Study Site
Braga, Portugal, 4710-243
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166
Clinical Study Site
Coimbra, Portugal, 3020-479
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167
Clinical Study Site
Faro, Portugal, 8000-386
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168
Clinical Study Site
Porto, Portugal, 4099-001
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169
Clinical Study Site
Suceagu, Cluj, Romania, 407062
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170
Clinical Study Site
Baia Mare, Romania, 430031
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171
Clinical Study Site
Bucharest, Romania, 22328
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172
Clinical Study Site
Cluj-Napoca, Romania, 407062
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173
Clinical Study Site
Cluj-Napoca, Romania, 407280
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174
Clinical Study Site
Craiova, Romania, 200542
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175
Clinical Study Site
Iași, Romania, 700106
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176
Clinical Study Site
Ovidiu, Romania, 905900
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177
Clinical Study Site
Timișoara, Romania, 300166
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178
Clinical Study Site
Belgrade, Serbia, 11040
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179
Clinical Study Site
Belgrade, Serbia, 11080
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180
Clinical Study Site
Kragujevac, Serbia, 34000
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181
Clinical Study Site
Novi Sad, Serbia, 21204
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182
Clinical Study Site
Badajoz, Spain, 06080
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183
Clinical Study Site
Badalona, Spain, 08916
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184
Clinical Study Site
Barcelona, Spain, 08003
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185
Clinical Study Site
Girona, Spain, 17007
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186
Clinical Study Site
Las Palmas, Spain, 35016
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187
Clinical Study Site
Lugo, Spain, 27002
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188
Clinical Study Site
Madrid, Spain, 28040
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189
Clinical Study Site
Málaga, Spain, 29011
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190
Clinical Study Site
Seville, Spain, 41014
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191
Clinical Study Site
Valencia, Spain, 46026
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192
Clinical Study Site
Zaragoza, Spain, 50009
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193
Clinical Study Site
Adana, Turkey (Türkiye), 01140
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194
Clinical Study Site
Ankara, Turkey (Türkiye), 06520
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195
Clinical Study Site
Antalya, Turkey (Türkiye), 07059
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196
Clinical Study Site
Diyarbakır, Turkey (Türkiye), 21280
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197
Clinical Study Site
Gaziantep, Turkey (Türkiye), 27060
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198
Clinical Study Site
Istanbul, Turkey (Türkiye), 34460
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199
Clinical Study Site
Istanbul, Turkey (Türkiye), 34722
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200
Clinical Study Site
İzmit, Turkey (Türkiye), 41380
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201
Clinical Study Site
Konya, Turkey (Türkiye), 42080
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202
Clinical Study Site
Seyhan, Turkey (Türkiye), 07059
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Research Team
S
Summit Clinical Trial Information
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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