Actively Recruiting
Clinical Study on Laparoscopic Resection of Splenic Artery Aneurysm With Preservation of Spleen
Led by Northern Jiangsu People's Hospital · Updated on 2025-07-08
10
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
This research investigates patients with splenic artery aneurysm, focusing on changes in immune function and blood flow dynamics in the splenic vein, proper hepatic artery, and portal vein after laparoscopic surgery. The study aims to understand how these changes relate to patient outcomes following the surgical removal of the aneurysm while preserving the spleen. Participants undergo laparoscopic resection of the splenic artery aneurysm performed by the same surgical team. After surgery, they receive standardized care and follow a postoperative treatment plan that includes medications and other therapies. Patients are monitored through blood tests and imaging to evaluate immune function and blood flow at multiple times: before surgery and at 7 days, 1 month, 3 months, 6 months, and 12 months after the operation. During the study, participants will have routine blood tests measuring various blood components and immune markers, as well as assessments of blood vessel diameter and flow velocity. Researchers will also monitor for thrombosis in the portal venous system throughout the first year. Follow-up visits and evaluations will allow tracking of recovery and treatment effects over a full year from surgery.
CONDITIONS
Brief Title
Clinical Study on Laparoscopic Resection of Splenic Artery Aneurysm With Preservation of Spleen
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 years or older
- Asymptomatic splenic artery aneurysms larger than 2 cm, ruptured aneurysms, or aneurysms growing more than 0.5 cm per year
- Aneurysm located in the main trunk of the splenic artery
- Informed consent to participate in the study
You will not qualify if you...
- Patients with malignancies
- Hepatic cirrhosis with portal hypertension
- Recent peptic ulcer disease
- History of hemorrhagic stroke
- Pregnancy
- Hematological diseases
- Uncontrolled hypertension
- Human immunodeficiency virus (HIV) infection
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 1 week or until discharge
Participants undergo laparoscopic resection of the splenic artery aneurysm with preservation of the spleen, followed by standardized post-operative care provided by the nursing team.
1 surgical procedure and hospitalization period
Duration - 12 months
Participants receive standardized post-operative treatment including pharmacotherapy and additional therapeutic interventions. Routine blood tests, liver function tests, coagulation function, immune function, and hemodynamics of the portal vein, proper hepatic artery, and splenic vein are monitored at multiple time points.
Follow-up visits at 7 days, 1 month, 3 months, 6 months, and 12 months post-surgery
Trial Site Locations
Total: 1 location
1
Clinical Medical College, Yangzhou University
Yangzhou, Jiangsu, China, China
Actively Recruiting
Research Team
G
Guo-Qing Jiang
D
Dou-Sheng Bai
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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