Common and well-documented HLA alleles over all of Europe and within European sub-regions: A catalogue from the European Federation for Immunogenetics.
A Sanchez-Mazas, J M Nunes, D Middleton...
https://pubmed.ncbi.nlm.nih.gov/28102034Actively Recruiting
Age: 18Years +
All Genders
Healthy Volunteers
ID06227468
A Clinical Study to Map the HLA Genomic Region and Its Potential Association With Selected Diseases in the Greek Population
Led by Athens LifeTech Park · Updated on 2024-01-26
12000
Participants Needed
8
Research Sites
65 weeks
Total Duration
On this page
Sponsors
A
Athens LifeTech Park
Lead Sponsor
G
Galatea.Bio
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are conducting the GENESIS clinical study to map the HLA genomic region in the Greek population and explore its possible links with various underlying diseases. This non-interventional, multicenter study aims to provide a pilot map of genetic variation in HLA that may be useful in medical research and clinical applications related to selected diseases. The study plans to include 12,000 participants over a total duration of 36 months. Each participant will attend one visit at a participating site during which they will provide demographic data, lifestyle information such as smoking and alcohol use, blood pressure measurements, details on diagnosed diseases and treatments, and recent laboratory test results if available. Buccal swab samples will be collected from each participant to extract DNA for HLA genotyping analysis. Selected samples will undergo further whole genome sequencing to investigate associations with autoimmune diseases. Participants will receive a personalized ancestry report after analysis completion. During the study visit, data collection includes demographic and health information, as well as laboratory and clinical test results from the past year. The genetic material from buccal swabs will be stored and processed for genetic analysis. Researchers will measure allele frequency of HLA alleles in the Greek population and assess the prevalence and risk associations of selected HLA-related diseases. The study's total duration is 36 months with results available at the end of this period.
CONDITIONS
Brief Title
A Clinical Study to Map the HLA Genomic Region in the Greek Population
Who Can Participate
Age: 18Years +
All Genders
Healthy Volunteers
Eligibility Criteria
You may qualify if you...
- Adults aged 18 years or older
- Possess a Greek social security number
- Visiting hospitals, clinics, or private labs as part of standard clinical practice in Greece
- Willing and able to provide written informed consent to participate according to the study protocol
You will not qualify if you...
- Unable to provide written informed consent (e.g., ICU patients, mental illness, lack of legal capacity)
- History of allogeneic bone marrow transplant
- History of stem cell transplant
- Blood transfusion within two weeks prior to buccal swab collection
- History of liver transplant
- Participation in an interventional clinical trial that might have impacted the HLA genome according to physician opinion
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Diagnostic Evaluation
Duration - 1 visit
Participants provide demographic information, health history, and recent clinical lab test results, and have buccal swab samples collected for genetic analysis.
1 visit (in-person)
Long-term Monitoring
Duration - Up to 36 months
Participants' genetic data are analyzed and an individualized ancestry report is made available to them if they choose to access it.
Trial Site Locations
Total: 8 locations
1
2nd Propaedeutic Department of Internal Medicine, Attikon University General Hospital
Chaïdári, Attica, Greece, 12462
Not Yet Recruiting
2
2nd Department of Neurology, AHEPA University Hospital
Thessaloniki, Thessaloniki, Greece, 54636
Not Yet Recruiting
3
Department of Respiratory Medicine, University General Hospital of Alexandroupolis
Alexandroupoli, Thrace, Greece, 68100
Actively Recruiting
4
Department of Infectious Diseases, 2nd Department of Internal Medicine, University General Hospital of Alexandroupolis
Alexandroupoli, Greece, 68100
Actively Recruiting
5
Department of Cardiology, University General Hospital of Heraklion
Heraklion, Greece, 71110
Not Yet Recruiting
6
Department of Rheumatology, University Hospital of Heraklion
Heraklion, Greece, 71110
Not Yet Recruiting
7
Department of Respiratory, University Hospital of Ioannina
Ioannina, Greece, 45500
Actively Recruiting
8
Department of Haematology, University General Hospital of Larissa
Larissa, Greece, 41110
Not Yet Recruiting
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Research Team
E
Efi Giannopoulou
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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Published Research Related To This Trial
HLA variation and disease.
Calliope A Dendrou, Jan Petersen, Jamie Rossjohn...
https://pubmed.ncbi.nlm.nih.gov/29292391Global Frequencies of Clinically Important HLA Alleles and Their Implications For the Cost-Effectiveness of Preemptive Pharmacogenetic Testing.
Yitian Zhou, Kristi Krebs, Lili Milani...
https://pubmed.ncbi.nlm.nih.gov/32535895