What is this study trying to find out about the HLA genomic region?

This study aims to map genetic variation in the HLA region among the Greek population and explore possible links with selected diseases. It helps researchers understand how HLA genes may relate to health conditions and could support future medical research. The study is sponsored by Athens LifeTech Park.

Who may be eligible for this clinical trial?

Adults aged 18 or older with a Greek social security number who are visiting hospitals or clinics in Greece may be eligible. Participants must be able to provide written consent and should not have recent transplants or blood transfusions. Please review eligibility criteria for more details.

Is there any cost to participate in this clinical trial?

Study-related care, including data collection and sample analysis, is provided at no cost. However, personal travel expenses to the study site may vary and are not guaranteed to be reimbursed.

Actively Recruiting

Age: 18Years +

All Genders

Healthy Volunteers

ID06227468

A Clinical Study to Map the HLA Genomic Region and Its Potential Association With Selected Diseases in the Greek Population

Led by Athens LifeTech Park · Updated on 2024-01-26

12000

Participants Needed

Research Sites

65 weeks

Total Duration

AI-Summary

What this Trial Is About

Researchers are conducting the GENESIS clinical study to map the HLA genomic region in the Greek population and explore its possible links with various underlying diseases. This non-interventional, multicenter study aims to provide a pilot map of genetic variation in HLA that may be useful in medical research and clinical applications related to selected diseases. The study plans to include 12,000 participants over a total duration of 36 months. Each participant will attend one visit at a participating site during which they will provide demographic data, lifestyle information such as smoking and alcohol use, blood pressure measurements, details on diagnosed diseases and treatments, and recent laboratory test results if available. Buccal swab samples will be collected from each participant to extract DNA for HLA genotyping analysis. Selected samples will undergo further whole genome sequencing to investigate associations with autoimmune diseases. Participants will receive a personalized ancestry report after analysis completion. During the study visit, data collection includes demographic and health information, as well as laboratory and clinical test results from the past year. The genetic material from buccal swabs will be stored and processed for genetic analysis. Researchers will measure allele frequency of HLA alleles in the Greek population and assess the prevalence and risk associations of selected HLA-related diseases. The studys total duration is 36 months with results available at the end of this period.

CONDITIONS

Brief Title

A Clinical Study to Map the HLA Genomic Region in the Greek Population

Who Can Participate

Age: 18Years +

All Genders

Healthy Volunteers

Eligibility Criteria

You may qualify if you...

Adults aged 18 years or older
Possess a Greek social security number
Visiting hospitals, clinics, or private labs as part of standard clinical practice in Greece
Willing and able to provide written informed consent to participate according to the study protocol

You will not qualify if you...

Unable to provide written informed consent (e.g., ICU patients, mental illness, lack of legal capacity)
History of allogeneic bone marrow transplant
History of stem cell transplant
Blood transfusion within two weeks prior to buccal swab collection
History of liver transplant
Participation in an interventional clinical trial that might have impacted the HLA genome according to physician opinion

Research Team

Efi Giannopoulou

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