Actively Recruiting
A Clinical Study of MK-2214 in People With Early Alzheimer's Disease (MK-2214-004)
Led by Merck Sharp & Dohme LLC · Updated on 2026-05-14
340
Participants Needed
76
Research Sites
197 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers want to know if the study treatment called MK-2214 works to slow certain changes in the brains of people with Alzheimer's disease (AD). AD is a type of dementia that can cause loss of memory, communication (such as speech), and decision-making skills. It can limit a person's ability to do daily tasks. MK-2214 is a study treatment designed to slow down AD. The goals of the study are to learn: * If MK-2214 slows the spread of tau in the brain compared to placebo. Tau is a protein that accumulates in AD \& damages brain cells. A placebo looks like the study treatment but has no study treatment in it. Using a placebo helps researchers better understand the effects of a study treatment. * About the safety of MK-2214 and if people tolerate it
CONDITIONS
Official Title
A Clinical Study of MK-2214 in People With Early Alzheimer's Disease (MK-2214-004)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Has mild cognitive impairment (MCI) or mild dementia due to Alzheimer's Disease (AD)
- Has a designated study partner who can fulfill the requirements of this study
- If on an approved AD therapy for symptomatic AD, the dosing regimen must have been stable for 3 months prior to screening
- Age between 50 and 85 years
You will not qualify if you...
- Has a known history of stroke or cerebrovascular disease
- Has diagnosis of a clinically relevant central nervous system disease other than AD or other condition that negatively impacts cognition or cognitive status chronically
- Has structural brain disease
- Has a history of seizures or epilepsy within 5 years before screening
- Has any other major central nervous system trauma, or infections that affect brain function
- Has major medical illness or unstable medical condition within 3 months before screening
- Has a severe, acute, or chronic medical or psychiatric condition or laboratory abnormality
- Has any immunological disease, which is not adequately controlled, or which requires treatment with biologics and/or immunosuppressants during the study
- Has a bleeding disorder that is not under adequate control
- Has a history of malignancy occurring within 5 years of screening
- Has a risk factor for corrected QT interval (QTc) prolongation
- Has liver disease
- Is unwilling or unable to undergo computed tomography (CT), positron emission tomography (PET), or magnetic resonance imaging (MRI) scan
- Resides in a nursing home or assisted care facility with need for direct continuous medical care and nursing supervision
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 76 locations
1
Irvine Clinical Research ( Site 1041)
Irvine, California, United States, 92614
Actively Recruiting
2
Healthy Brain Clinic ( Site 1005)
Long Beach, California, United States, 90804
Actively Recruiting
3
Inglewood Clinical ( Site 1062)
Los Angeles, California, United States, 90056
Actively Recruiting
4
Anderson Clinical Research ( Site 1024)
Redlands, California, United States, 92374
Actively Recruiting
5
UCSF Memory and Aging Center ( Site 1031)
San Francisco, California, United States, 94158
Actively Recruiting
6
Syrentis Clinical Research ( Site 1001)
Santa Ana, California, United States, 92705
Actively Recruiting
7
Yale University, Alzheimer's Disease Research Unit ( Site 1059)
New Haven, Connecticut, United States, 06510
Actively Recruiting
8
JEM Research Institute ( Site 1046)
Atlantis, Florida, United States, 33462
Actively Recruiting
9
Neuropsychiatric Research Center of Southwest Florida ( Site 1003)
Fort Myers, Florida, United States, 33912
Actively Recruiting
10
Indago Research & Health Center, Inc ( Site 1044)
Hialeah, Florida, United States, 33012
Actively Recruiting
11
K2 Medical Research ( Site 1047)
Maitland, Florida, United States, 32750
Actively Recruiting
12
ClinCloud LLC ( Site 1039)
Melbourne, Florida, United States, 32940
Actively Recruiting
13
Aqualane Clinical Research ( Site 1035)
Naples, Florida, United States, 34105
Actively Recruiting
14
Suncoast Clinical Research ( Site 1007)
New Port Richey, Florida, United States, 34652
Actively Recruiting
15
Renstar Medical Research ( Site 1012)
Ocala, Florida, United States, 34471
Actively Recruiting
16
Charter Research - Orlando ( Site 1051)
Orlando, Florida, United States, 32803
Actively Recruiting
17
Axiom Brain Health ( Site 1029)
Tampa, Florida, United States, 33609
Actively Recruiting
18
K2 Medical Research ( Site 1020)
Tampa, Florida, United States, 33634
Actively Recruiting
19
Charter Research - Lady Lake ( Site 1019)
The Villages, Florida, United States, 32162
Actively Recruiting
20
Conquest Research LLC ( Site 1053)
Winter Park, Florida, United States, 32789
Actively Recruiting
21
CenExel iResearch, LLC ( Site 1015)
Decatur, Georgia, United States, 30030
Actively Recruiting
22
Alexian Brothers Medical Center-Neurosciences ( Site 1017)
Elk Grove Village, Illinois, United States, 60007
Actively Recruiting
23
Boston Center for Memory ( Site 1008)
Newton, Massachusetts, United States, 02459
Actively Recruiting
24
Clinical Research Professionals ( Site 1004)
Chesterfield, Missouri, United States, 63005
Actively Recruiting
25
The Cognitive and Research Center of New Jersey - Ridgewood ( Site 1064)
Ridgewood, New Jersey, United States, 07450
Actively Recruiting
26
The Cognitive and Research Center of NJ ( Site 1057)
Springfield, New Jersey, United States, 07081
Actively Recruiting
27
CenExel- AMRI ( Site 1018)
Toms River, New Jersey, United States, 08755
Actively Recruiting
28
Alzheimer Disease Research Center (ADRC) ( Site 1000)
Albany, New York, United States, 12208
Actively Recruiting
29
Mid Hudson Medical Research ( Site 1050)
New Windsor, New York, United States, 12553
Actively Recruiting
30
Basil Clinical ( Site 1065)
Queens, New York, United States, 11413
Actively Recruiting
31
AMC Research, LLC ( Site 1006)
Matthews, North Carolina, United States, 28105
Actively Recruiting
32
Insight Clinical Trials ( Site 1011)
Independence, Ohio, United States, 44131
Actively Recruiting
33
Neuro-Behavioral Clinical Research ( Site 1028)
North Canton, Ohio, United States, 44720
Actively Recruiting
34
Flourish Research ( Site 1048)
Plymouth Meeting, Pennsylvania, United States, 19462
Actively Recruiting
35
Gadolin Research ( Site 1032)
Beaumont, Texas, United States, 77702
Actively Recruiting
36
Horizon Clinical Research Center - Houston ( Site 1026)
Cypress, Texas, United States, 77429
Actively Recruiting
37
Organizacion Medica de Investigacion ( Site 0401)
Ciudad de Buenos Aires, Buenos Aires F.D., Argentina, C1015ABO
Actively Recruiting
38
Centro de Educación Médica e Investigaciones clínicas "Dr. Norberto Quirno" (CEMIC) ( Site 0404)
Ciudad de Buenos Aires, Buenos Aires F.D., Argentina, C1431FWO
Actively Recruiting
39
Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia (FLENI) ( Site 0400)
Caba, Argentina, C1428AQK
Actively Recruiting
40
Southern Neurology ( Site 0306)
Kogarah, New South Wales, Australia, 2217
Actively Recruiting
41
KARA Institute for Neurological Diseases ( Site 0302)
Macquarie Park, New South Wales, Australia, 2113
Actively Recruiting
42
Austin Health ( Site 0300)
Ivanhoe, Victoria, Australia, 3079
Actively Recruiting
43
HammondCare ( Site 0301)
Malvern, Victoria, Australia, 3144
Actively Recruiting
44
Cliniques universitaires Saint-Luc ( Site 3001)
Brussels, Bruxelles-Capitale, Region de, Belgium, 1200
Actively Recruiting
45
UZ Leuven ( Site 3000)
Leuven, Vlaams-Brabant, Belgium, 3000
Actively Recruiting
46
AZ Groeninge Campus Kennedylaan ( Site 3002)
Kortrijk, West-Vlaanderen, Belgium, 8500
Actively Recruiting
47
Ottawa Memory Clinic ( Site 2001)
Ottawa, Ontario, Canada, K1Z 1G3
Actively Recruiting
48
Toronto Western Hospital ( Site 2004)
Toronto, Ontario, Canada, M5T 2S8
Actively Recruiting
49
Clinique Mémoire de Montreal ( Site 2000)
Montreal, Quebec, Canada, H3G 1H9
Actively Recruiting
50
National Center for Geriatrics and Gerontology ( Site 9002)
Ōbu, Aichi-ken, Japan, 474-8511
Actively Recruiting
51
Chibaken Saiseikai Narashino Hospital ( Site 9000)
Narashino, Chiba, Japan, 275-8580
Actively Recruiting
52
Association of Healthcare Corporation Koukankai Koukan Clinic ( Site 9016)
Kawasaki, Kanagawa, Japan, 210-0852
Actively Recruiting
53
Mie University Hospital ( Site 9011)
Tsu, Mie-ken, Japan, 514-8507
Actively Recruiting
54
Katayama Medical Clinic ( Site 9005)
Kurashiki, Okayama-ken, Japan, 710-0813
Actively Recruiting
55
National Hospital Organization Hizen Psychiatric Medical Center ( Site 9004)
Kanzaki-gun, Saga-ken, Japan, 8420192
Actively Recruiting
56
Tokyo Medical University Hospital ( Site 9003)
Shinjuku, Tokyo, Japan, 160-0023
Actively Recruiting
57
Inage Neurology and Memory Clinic ( Site 9001)
Chiba, Japan, 263-0043
Actively Recruiting
58
Kyushu University Hospital ( Site 9010)
Fukuoka, Japan, 812-8582
Actively Recruiting
59
Okayama City General Medical Center Okayama City Hospital ( Site 9008)
Okayama, Japan, 700-8557
Actively Recruiting
60
Brain Research Center Den Bosch B.V. ( Site 5001)
's-Hertogenbosch, North Brabant, Netherlands, 5223 LA
Actively Recruiting
61
Brain Research Center. ( Site 5000)
Amsterdam, North Holland, Netherlands, 1081 GN
Actively Recruiting
62
Brain Research Center Zwolle ( Site 5002)
Zwolle, Overijssel, Netherlands, 8025 AZ
Actively Recruiting
63
Hanyang University Hospital ( Site 0200)
Seoul, South Korea, 04763
Actively Recruiting
64
Samsung Medical Center ( Site 0202)
Seoul, South Korea, 06351
Actively Recruiting
65
Ewha Womans University Seoul Hospital ( Site 0201)
Seoul, South Korea, 07804
Actively Recruiting
66
Hospital Universitari Mutua Terrassa ( Site 6004)
Terrassa, Barcelona, Spain, 08222
Actively Recruiting
67
Fundació ACE ( Site 6003)
Barcelona, Catalonia, Spain, 08028
Actively Recruiting
68
Hospital del Mar ( Site 6001)
Barcelona, Spain, 08003
Actively Recruiting
69
Hospital Clinic i Provincial ( Site 6002)
Barcelona, Spain, 08036
Actively Recruiting
70
Scottish Brain Sciences Aberdeen ( Site 8001)
Aberdeen, Aberdeen City, United Kingdom, AB25 2XE
Actively Recruiting
71
Scottish Brain Sciences ( Site 8000)
Edinburgh, Edinburgh, City of, United Kingdom, EH12 5PJ
Actively Recruiting
72
Moorgreen Hospital ( Site 8004)
Southampton, Hampshire, United Kingdom, SO30 3JB
Actively Recruiting
73
Leonard Wolfson Experimental Neurology Centre (LWENC) ( Site 8006)
London, London, City of, United Kingdom, NW1 2PG
Actively Recruiting
74
Warneford Hospital ( Site 8007)
Oxford, Oxfordshire, United Kingdom, OX3 7JX
Actively Recruiting
75
Remind UK ( Site 8003)
Bath, Somerset, United Kingdom, BA1 3NG
Actively Recruiting
76
Re:Cognition Health - Birmingham ( Site 8002)
Birmingham, United Kingdom, B16 8LT
Actively Recruiting
Research Team
T
Toll Free Number
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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