Impact of Polyethylene Glycol (PEG) Bowel Preparation on Intestinal Microbiota Composition and Diversity in Patients Undergoing Appendectomy

What this Trial Is About

This research investigates the impact of polyethylene glycol (PEG) bowel preparation on the gut microbiota in people who have had an appendectomy compared to those who have not. It explores how PEG, commonly used before colonoscopy, may affect intestinal microbes and how the appendix plays a role in protecting and restoring the gut microbiome. The study focuses on the differences in microbial changes and recovery between appendectomy patients and healthy controls over time. Participants will undergo colonoscopy with PEG laxatives used for bowel preparation following standard clinical procedures. Two groups are studied: one with a history of appendectomy or right hemicolectomy including appendectomy, and a control group without such history. Fecal samples will be collected at five time points: before colonoscopy, at the first non-watery stool after colonoscopy, and at one, three, and six months post-colonoscopy for detailed microbial analysis. During the study, participants will provide stool samples and complete questionnaires about their intestinal and general health. Researchers will analyze changes in gut microbes, diversity, and metabolic functions over six months after colonoscopy. Participant identities will be kept confidential, and they can withdraw at any time. The study will share progress updates and individual results with participants throughout the trial.

Clinical Study of PEG Bowel Preparation in Appendectomy Patients