Actively Recruiting
Clinical Study of Perioperative Sleep Disorders in Cardiac Surgery
Led by Nanjing First Hospital, Nanjing Medical University · Updated on 2025-02-07
180
Participants Needed
2
Research Sites
46 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The aim of this clinical trial is to understand the effects of dexmedetomidine and esketamine on postoperative sleep in patients undergoing cardiac surgery. The main questions it aims to answer are: Does dexmedetomidine or esketamine prevent the development of postoperative sleep disturbances? Which one works better? The researchers compared dexmedetomidine and esketamine with saline (a drug-free solvent) to see if dexmedetomidine and esketamine prevented the development of postoperative sleep disturbances. Participants will: 1. Intraoperative continuous infusion of dexmedetomidine, esketamine or saline until the end of surgery 2. Postoperative sleep was assessed on the first and third postoperative days using a sleep rating scale
CONDITIONS
Official Title
Clinical Study of Perioperative Sleep Disorders in Cardiac Surgery
Who Can Participate
Eligibility Criteria
You may qualify if you...
- ASA class II-III
- NYHA class I-III
- Ejection fraction (EF) of 50% or higher
- Planned cardiac surgery using extracorporeal circulation
- Age between 40 and 75 years
You will not qualify if you...
- Undergoing a second heart surgery
- Mental retardation, deafness, or communication impairments
- Previous neurological or psychiatric disorders
- History of sleep disorders
- Alcohol, drug, or psychotropic substance abuse
- Significant liver or kidney dysfunction affecting drug metabolism
- Contraindication to dexmedetomidine or esketamine use
AI-Screening
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Trial Site Locations
Total: 2 locations
1
Nanjing First Hospital，Nanjing Medical University
Nanjing, Jiangsu, China, 210006
Not Yet Recruiting
2
Nanjing First Hospital
Nanjing, Jiangsu, China, 210006
Actively Recruiting
Research Team
K
Kuang xueyi
CONTACT
H
hongwei shi
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
3
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