Study Comparing Dexmedetomidine and Esketamine for Preventing Sleep Problems After Cardiac Surgery

What this Trial Is About

Researchers are evaluating the effects of dexmedetomidine and esketamine on sleep quality after heart surgery. The study aims to find out if these drugs can prevent postoperative sleep disturbances and which is more effective, comparing them to a saline placebo. This is a Phase 4 randomized trial focused on patients undergoing cardiac surgery with extracorporeal circulation. Participants are randomly assigned to receive an intraoperative continuous infusion of either dexmedetomidine at 0.3 ugkgh, esketamine at 0.3 mgkgh, or saline until the surgery ends. The study involves three groups a dexmedetomidine group, an esketamine group, and a saline control group. The infusion happens during surgery only. During the first and third days after surgery, participants sleep is assessed using a sleep rating scale. Researchers also monitor pain levels at 24 and 48 hours, use of pain medications, anxiety and depression at 1 and 3 days, postoperative complications at 48 hours, and delirium from day 1 to 7. The study runs from October 2024 to September 2025 and involves detailed monitoring of recovery quality and sleep outcomes.

Clinical Study of Perioperative Sleep Disorders in Cardiac Surgery