Actively Recruiting
Clinical Study of PSMA-targeted CAR-T Cells in the Treatment of Castration-resistant Prostate Cancer
Led by The Affiliated Hospital of Xuzhou Medical University · Updated on 2022-04-29
20
Participants Needed
1
Research Sites
208 weeks
Total Duration
On this page
Sponsors
T
The Affiliated Hospital of Xuzhou Medical University
Lead Sponsor
X
Xuzhou Medical University
Collaborating Sponsor
AI-Summary
What this Trial Is About
This is an experimental study to evaluate the safety and effectiveness of PSMA-targeted CAR-T cells in the treatment of castration-resistant prostate cancer.
CONDITIONS
Official Title
Clinical Study of PSMA-targeted CAR-T Cells in the Treatment of Castration-resistant Prostate Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male patients aged from 18 to 75 years old
- ECOG performance score of 2 or less
- Diagnosed with castration-resistant prostate cancer, with or without distant metastasis
- Previous new endocrine therapy was ineffective
- Previous treatment with citabine or cabazitaxel was ineffective
- Presence of measurable or evaluable lesions
- Good liver function with ALT/AST less than 3 times the upper limit of normal
- Kidney function with creatinine less than 220 micromol/L
- Lung function with oxygen saturation of at least 95%
- Heart function with left ventricular ejection fraction of 40% or more
- Willingness to participate and sign informed consent
You will not qualify if you...
- Infectious diseases such as HIV, active hepatitis B or C, or active tuberculosis
- Insufficient lymphocyte transfection or amplification under CD3/CD28 co-stimulation
- Abnormal vital signs or inability to cooperate with study procedures
- Mental illness preventing cooperation with treatment and evaluation
- Severe allergies or allergic history, especially to IL-2
- Systemic or severe local infections requiring treatment
- Severe dysfunction of heart, lung, brain, liver, kidney, or other major organs
- Presence of other tumors
- Any other reasons deemed by doctors to exclude participation
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Affiliated Hospital of Xuzhou Medical University
Xuzhou, Jiangsu, China, 221000
Actively Recruiting
Research Team
H
Hailong Li, M.D/Ph.D
CONTACT
Q
Qing Zhang, Ph.D
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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