Actively Recruiting

Phase 3
Age: 18Years +
All Genders
NCT06618664

A Clinical Study of SHR-8068 Combined With Adebrelimab and Bevacizumab Versus Sintilimab or Atezolizumab Combined With Bevacizumab for the Treatment of Advanced Hepatocellular Carcinoma

Led by Suzhou Suncadia Biopharmaceuticals Co., Ltd. · Updated on 2026-05-04

590

Participants Needed

1

Research Sites

317 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

THis study aims to evaluate the efficacy of SHR-8068 combined with Adebrelimab and Bevacizumab compared with Sintilimab or Atezolizumab combined with Bevacizumab for the first-line treatment of advanced HCC.

CONDITIONS

Official Title

A Clinical Study of SHR-8068 Combined With Adebrelimab and Bevacizumab Versus Sintilimab or Atezolizumab Combined With Bevacizumab for the Treatment of Advanced Hepatocellular Carcinoma

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  1. Able and willing to provide a written informed consent.
  2. ≥ 18 years old, both male and female.
  3. Unresectable locally advanced or metastatic HCC confirmed by histopathologically/cytologically.
  4. At least one measurable lesion based on RECIST v1.1 criteria.
  5. Barcelona clinic liver cancer: Stage B or C.
  6. No previous systemic antitumor therapy for HCC.
  7. ECOG PS of 0-1.
  8. Child-Pugh score of A or B7.
  9. Expected survival period ≥ 12 weeks.
  10. Adequate organ function.
  11. Blood pregnancy negative (women of childbearing age) and non-breastfeeding, effective contraception.
Not Eligible

You will not qualify if you...

  1. Hepatic cholangiocarcinoma, mixed hepatocellular carcinoma -cholangiocarcinoma, sarcomatoid hepatocellular carcinoma and fibrolamellar hepatocellular carcinoma.
  2. Patients with other malignancies currently or within the past 5 years.
  3. With known severe allergic reactions to any other monoclonal antibodies.
  4. Patients with known CNS metastasis or hepatic encephalopathy.
  5. Patients with liver tumor burden greater than 50% of total liver in volume or received liver transplants.
  6. Patients with symptomatic ascites or pleural effusion.
  7. Patients with hypertension which cannot be well controlled by antihypertensives.
  8. Uncontrolled cardiac diseases or symptoms.
  9. Known hereditary or acquired bleeding (e.g., coagulopathy) or a tendency to clot (e.g., hemophiliacs).
  10. Major vascular disease occurred in the 6 months before randomization.
  11. Gastrointestinal perforation or gastrointestinal fistula within 6 months before randomization.
  12. Major surgery within 28 days before randomization or expected to require major surgery during the study period.
  13. Active infection, or fever of unknown cause ≥ 38.5℃ in the first 7 days of randomization, or WBC > 15×109/L at baseline.
  14. Known positive history of human immunodeficiency virus test or acquired immunodeficiency syndrome, known HBV infection, known HCV infection.
  15. Patients who received live vaccines within 28 days before randomization, or are expected to be vaccinated during the treatment period
  16. Patients with other potential factors that may affect the study results.

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 1 location

1

Anhui Provincial Hospital

Hefei, Anhui, China, 230000

Actively Recruiting

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Research Team

X

Xin Shi

CONTACT

Y

Ying Sun

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

2

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