Actively Recruiting
A Clinical Study of Sotatercept (MK-7962) in People With Pulmonary Arterial Hypertension (MK-7962-038)
Led by Merck Sharp & Dohme LLC · Updated on 2026-05-12
815
Participants Needed
107
Research Sites
395 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are looking for more ways to treat PAH. In PAH, the blood vessels in the lungs become thick and narrow, which makes it harder for blood to flow. This causes high blood pressure in the lungs and overworks the heart. PAH can make it hard to breathe and be active. Some standard (usual) treatments for PAH can treat symptoms of PAH but do not stop PAH from getting worse. Sotatercept is a study medicine designed to treat PAH. It is a targeted therapy, which is a treatment that works on certain proteins that play a role in causing PAH. This is a long-term follow-up (LTFU) study. People who took part in certain other studies testing sotatercept for PAH may be able to join this study. The goal of this study is to learn about the long-term safety of sotatercept and if people tolerate it when taken with standard PAH treatment over a longer period of time.
CONDITIONS
Official Title
A Clinical Study of Sotatercept (MK-7962) in People With Pulmonary Arterial Hypertension (MK-7962-038)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Completed their previous PAH sotatercept clinical study and did not discontinue early
- Willing to follow the study visit schedule and comply with all study requirements
- Able to understand and provide documented informed consent
You will not qualify if you...
- Did not participate in a sotatercept PAH parent study
- Missed more than the equivalent of 4 consecutive doses between the end of the parent study and the start of this study
- Have an ongoing serious adverse event from a sotatercept PAH study assessed as possibly or probably related to sotatercept
- Are pregnant or breastfeeding
- Are an immediate family member of investigational site or Sponsor staff involved in this study
- Currently enrolled in another investigational product study other than a sotatercept study
- Are incapacitated
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 107 locations
1
Pulmonary Associates, PA ( Site 1008)
Phoenix, Arizona, United States, 85032
Active, Not Recruiting
2
University of California San Diego Health ( Site 1002)
La Jolla, California, United States, 92039
Active, Not Recruiting
3
UCSF Helen Diller Medical Center at Parnassus Heights ( Site 1019)
San Francisco, California, United States, 94143
Active, Not Recruiting
4
Jeffrey S. Sager, MD Medical Corporation ( Site 1060)
Santa Barbara, California, United States, 93105-5316
Actively Recruiting
5
Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center ( Site 1028)
Torrance, California, United States, 90502
Actively Recruiting
6
University of Colorado Hospital ( Site 1013)
Aurora, Colorado, United States, 80045
Active, Not Recruiting
7
Mayo Clinic Jacksonville ( Site 1045)
Jacksonville, Florida, United States, 32224
Actively Recruiting
8
AdventHealth Orlando ( Site 1058)
Orlando, Florida, United States, 32803
Actively Recruiting
9
University of Kansas Medical Center ( Site 1020)
Kansas City, Kansas, United States, 66160
Actively Recruiting
10
Norton Pulmonary Specialists ( Site 1066)
Louisville, Kentucky, United States, 40202
Actively Recruiting
11
Johns Hopkins University ( Site 1036)
Baltimore, Maryland, United States, 21287
Actively Recruiting
12
Tufts Medical Center ( Site 1012)
Boston, Massachusetts, United States, 02111
Actively Recruiting
13
University Of Nebraska Medical Center ( Site 1053)
Omaha, Nebraska, United States, 68198-5990
Active, Not Recruiting
14
Weill Cornell Medical Center ( Site 1046)
New York, New York, United States, 10021
Active, Not Recruiting
15
Duke University Medical Center ( Site 1026)
Durham, North Carolina, United States, 27710-4000
Actively Recruiting
16
The Carl and Edyth Lindner Center for Research and Education at the Christ Hospital ( Site 1001)
Cincinnati, Ohio, United States, 45219
Actively Recruiting
17
University of Cincinnati Medical Center ( Site 1035)
Cincinnati, Ohio, United States, 45219
Actively Recruiting
18
Ohio State University Wexner Medical Center ( Site 1032)
Columbus, Ohio, United States, 43210
Active, Not Recruiting
19
Oregon Health & Science University ( Site 1054)
Portland, Oregon, United States, 97239
Actively Recruiting
20
University of Pittsburgh Medical Center - Presbyterian Hosp. ( Site 1059)
Pittsburgh, Pennsylvania, United States, 15213
Actively Recruiting
21
Rhode Island Hospital ( Site 1033)
Providence, Rhode Island, United States, 02903
Actively Recruiting
22
Medical University of South Carolina ( Site 1003)
Charleston, South Carolina, United States, 29425
Actively Recruiting
23
CHI St. Luke's Health Baylor College of Medicine Medical Center ( Site 1044)
Houston, Texas, United States, 77030
Actively Recruiting
24
Houston Methodist Hospital ( Site 1009)
Houston, Texas, United States, 77030
Actively Recruiting
25
Instituto de Investigaciones Clinicas Quilmes ( Site 1903)
Quilmes, Buenos Aires, Argentina, B1878GEG
Active, Not Recruiting
26
Instituto Médico Río Cuarto ( Site 1907)
Río Cuarto, Córdoba Province, Argentina, X5800AEV
Active, Not Recruiting
27
Sanatorio Parque ( Site 1905)
Rosario, Santa Fe Province, Argentina, S2000CUB
Active, Not Recruiting
28
Instituto Cardiovascular de Rosario ( Site 1906)
Rosario, Santa Fe Province, Argentina, S2000DSR
Active, Not Recruiting
29
Hospital Provincial del Centenario ( Site 1912)
Rosario, Santa Fe Province, Argentina, S2002KDS
Active, Not Recruiting
30
Sanatorio Allende ( Site 1908)
Córdoba, Argentina, X5021FPQ
Active, Not Recruiting
31
Hospital Provincial Dr. Jose M. Cullen ( Site 1902)
Santa Fe, Argentina, S3000EOZ
Active, Not Recruiting
32
Royal Prince Alfred Hospital ( Site 1106)
Camperdown, New South Wales, Australia, 2050
Actively Recruiting
33
The Prince Charles Hospital ( Site 1104)
Chermside, New South Wales, Australia, 4032
Actively Recruiting
34
John Hunter Hospital ( Site 1101)
New Lambton Heights, New South Wales, Australia, 2305
Active, Not Recruiting
35
Royal Hobart Hospital ( Site 1107)
Hobart, Tasmania, Australia, 7000
Actively Recruiting
36
Fiona Stanley Hospital ( Site 1103)
Murdoch, Western Australia, Australia, 6150
Actively Recruiting
37
Université Libre de Bruxelles - Hôpital Erasme ( Site 1402)
Brussels, Bruxelles-Capitale, Region de, Belgium, 1070
Actively Recruiting
38
UZ Leuven ( Site 1401)
Leuven, Vlaams-Brabant, Belgium, 3000
Actively Recruiting
39
Peter Lougheed Centre ( Site 2102)
Calgary, Alberta, Canada, T1Y 6J4
Actively Recruiting
40
Fundación Neumológica Colombiana ( Site 3403)
Bogotá, Bogota D.C., Colombia, 110131
Actively Recruiting
41
Clínica Imbanaco S.A.S ( Site 3404)
Cali, Valle del Cauca Department, Colombia, 760042
Actively Recruiting
42
Klinicki Bolnicki Centar Split ( Site 3901)
Split, Split-Dalmatia County, Croatia, 21000
Active, Not Recruiting
43
Institut Klinicke a Experimentalni Mediciny ( Site 2202)
Prague, Praha 4, Czechia, 140 21
Active, Not Recruiting
44
Vseobecna fakultni nemocnice v Praze ( Site 2201)
Prague, Czechia, 128 08
Active, Not Recruiting
45
Rigshospitalet ( Site 3802)
København Ø, Capital Region, Denmark, 2100
Active, Not Recruiting
46
Aarhus Universitetshospital, Skejby ( Site 3801)
Aarhus, Central Jutland, Denmark, 8200
Active, Not Recruiting
47
Centre Hospitalier Universitaire de Nice - Hopital Pasteur ( Site 1311)
Nice, Alpes-Maritimes, France, 06300
Actively Recruiting
48
CHU Bordeaux Haut-Leveque ( Site 1312)
Pessac, Aquitaine, France, 33604
Actively Recruiting
49
Nouvel Hôpital Civil (NHC) ( Site 1307)
Strasbourg, Bas-Rhin, France, 67000
Actively Recruiting
50
Hopital Cavale Blanche ( Site 1314)
Brest, Finistere, France, 29609
Actively Recruiting
51
Hopital Larrey ( Site 1315)
Toulouse, Haute-Garonne, France, 31400
Active, Not Recruiting
52
CHU de Grenoble Hopital Nord ( Site 1303)
La Tronche, Isere, France, 38700
Active, Not Recruiting
53
Hopital Nord Laennec ( Site 1309)
Saint-Herblain, Loire-Atlantique, France, 44800
Actively Recruiting
54
CHU Angers ( Site 1313)
Angers, Maine-et-Loire, France, 49100
Actively Recruiting
55
CENTRE HOSPITALIER UNIVERSITAIRE DE LILLE ( Site 1306)
Lille, Nord, France, 59037
Actively Recruiting
56
Centre Hospitalier Universitaire de Saint Étienne- Hôpital Nord-Medecine Vasculaire et Therapeutique ( Site 1302)
Saint-Étienne-de-Montluc, Pays de la Loire Region, France, 42055
Actively Recruiting
57
Hôpital Louis Pradel ( Site 1317)
Lyon, Rhone, France, 69677
Actively Recruiting
58
Hôpitaux Universitaires Paris Sud - Hôpital Bicêtre-Pneumologie ( Site 1304)
Le Kremlin-Bicêtre, Val-de-Marne, France, 94275
Actively Recruiting
59
CHU de la Miletrie Poitiers ( Site 1316)
Poitiers, Vienne, France, 86021
Actively Recruiting
60
Thoraxklinik-Heidelberg gGmbH ( Site 1509)
Heidelberg, Baden-Wurttemberg, Germany, 69126
Actively Recruiting
61
Krankenhaus Neuwittelsbach ( Site 1510)
München, Bavaria, Germany, 80639
Active, Not Recruiting
62
Medizinische Hochschule Hannover ( Site 1505)
Hanover, Lower Saxony, Germany, 30625
Actively Recruiting
63
Universitätsklinikum Leipzig ( Site 1508)
Leipzig, Saxony, Germany, 04103
Actively Recruiting
64
Universitätsklinikum Halle ( Site 1502)
Halle, Saxony-Anhalt, Germany, 06120
Actively Recruiting
65
DRK Kliniken Berlin Westend ( Site 1507)
Berlin, Germany, 14050
Actively Recruiting
66
ATTIKON GENERAL UNIVERSITY HOSPITAL ( Site 3604)
Athens, Attica, Greece, 124 62
Actively Recruiting
67
AHEPA University General Hospital of Thessaloniki-1st Cardiology Clinic ( Site 3601)
Thessaloniki, Greece, 546 36
Actively Recruiting
68
Carmel Hospital ( Site 1705)
Haifa, Israel, 3436212
Actively Recruiting
69
Haddasah Medical Center ( Site 1711)
Jerusalem, Israel, 9112001
Actively Recruiting
70
Rabin Medical Center ( Site 1703)
Petah Tikva, Israel, 4941492
Active, Not Recruiting
71
Sheba Medical Center ( Site 1701)
Ramat Gan, Israel, 5265601
Active, Not Recruiting
72
Fondazione IRCCS San Gerardo dei Tintori ( Site 2406)
Monza, Lombardy, Italy, 20900
Actively Recruiting
73
Ospedale San Giuseppe ( Site 2403)
Milan, Milano, Italy, 20123
Actively Recruiting
74
AOU Policlinico Umberto I ( Site 2402)
Rome, Roma, Italy, 00161
Actively Recruiting
75
A.O.R.N. Ospedale dei Colli - Monaldi V. ( Site 2407)
Naples, Italy, 80131
Actively Recruiting
76
Radboud University Nijmegen Medical Centre ( Site 2605)
Nijmegen, Gelderland, Netherlands, 6525 GA
Active, Not Recruiting
77
Amsterdam UMC, locatie VUmc ( Site 2601)
Amsterdam, North Holland, Netherlands, 1081 HV
Active, Not Recruiting
78
Waikato Hospital ( Site 2702)
Hamilton, Waikato Region, New Zealand, 3240
Active, Not Recruiting
79
Krakowski Szpital Specjalistyczny im. Jana Pawla II ( Site 2801)
Krakow, Lesser Poland Voivodeship, Poland, 31-202
Actively Recruiting
80
Hospital Garcia de Orta ( Site 3501)
Almada, Setúbal District, Portugal, 2805-267
Actively Recruiting
81
Hospital Pulido Valente ( Site 3503)
Lisbon, Portugal, 1769-001
Actively Recruiting
82
University Clinical Hospital Center of Serbia ( Site 2901)
Belgrade, Beograd, Serbia, 11000
Actively Recruiting
83
Institute for pulmonary diseases of Vojvodina ( Site 2906)
Novi Sad, Beograd, Serbia, 21000
Active, Not Recruiting
84
Institute for Cardiovascular Diseases Dedinje ( Site 2903)
Belgrade, Serbia, 11000
Active, Not Recruiting
85
Gachon University Gil Medical Center ( Site 3103)
Incheon, South Korea, 21565
Active, Not Recruiting
86
Severance Hospital, Yonsei University Health System ( Site 3101)
Seoul, South Korea, 03722
Active, Not Recruiting
87
Samsung Medical Center ( Site 3106)
Seoul, South Korea, 06351
Active, Not Recruiting
88
Hospital Universitario de Son Espases ( Site 1611)
Palma de Mallorca, Balearic Islands, Spain, 07120
Active, Not Recruiting
89
Hospital Universitario Marques de Valdecilla ( Site 1601)
Santander, Cantabria, Spain, 39008
Active, Not Recruiting
90
Hospital Universitari Vall D Hebron ( Site 1605)
Barcelona, Catalonia, Spain, 08035
Active, Not Recruiting
91
Hospital Universitario Puerta de Hierro-Majadahonda ( Site 1604)
Majadahonda, Madrid, Spain, 28222
Active, Not Recruiting
92
Hospital Universitario 12 de Octubre ( Site 1603)
Madrid, Madrid, Comunidad de, Spain, 28041
Actively Recruiting
93
Hospital Clinic de Barcelona ( Site 1602)
Barcelona, Spain, 08036
Active, Not Recruiting
94
Hospital Universitario La Paz ( Site 1610)
Madrid, Spain, 28046
Active, Not Recruiting
95
Hospital General Universitario Ramon y Cajal ( Site 1609)
Madrid, Spain, 28048
Active, Not Recruiting
96
HOSPITAL GENERAL UNIVERSITARIO DE TOLEDO ( Site 1607)
Toledo, Spain, 45007
Actively Recruiting
97
Sahlgrenska Universitetssjukhuset ( Site 3201)
Gothenburg, Västra Götaland County, Sweden, 41346
Active, Not Recruiting
98
UniversitätsSpital Zürich ( Site 3301)
Zurich, Switzerland, 8091
Active, Not Recruiting
99
Kaohsiung Veteran General Hospital ( Site 3702)
Kaohsiung City, Taiwan, 813
Active, Not Recruiting
100
National Cheng Kung University Hospital ( Site 3703)
Tainan, Taiwan, 704302
Active, Not Recruiting
101
Papworth Hospital NHS Foundation Trust ( Site 1208)
Cambridge, Cambridgeshire, United Kingdom, CB2 0AY
Active, Not Recruiting
102
Golden Jubilee National Hospital ( Site 1204)
Glasgow, Glasgow City, United Kingdom, G81 4DY
Active, Not Recruiting
103
Royal Free Hospital ( Site 1202)
London, London, City of, United Kingdom, NW3 2QG
Active, Not Recruiting
104
Royal Brompton Hospital ( Site 1206)
London, London, City of, United Kingdom, SW3 6NP
Active, Not Recruiting
105
Hammersmith Hospital ( Site 1203)
London, London, City of, United Kingdom, W12 0HS
Active, Not Recruiting
106
Freeman Hospital ( Site 1205)
Newcastle upon Tyne, United Kingdom, NE7 7DN
Active, Not Recruiting
107
Royal Hallamshire Hospital ( Site 1207)
Sheffield, United Kingdom, S10 2JF
Active, Not Recruiting
Research Team
T
Toll Free Number
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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