Actively Recruiting
Clinical Study of Taurine Combined With Neoadjuvant Chemo-Immunotherapy for Treatment of Locally Advanced Gastric Cancer
Led by Tang-Du Hospital · Updated on 2025-01-07
96
Participants Needed
6
Research Sites
95 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This project aims to evaluate the efficacy and safety of oral taurine supplementation combined with PD-1 inhibitor (serplulimab) and chemotherapy in inducing systemic CD8+ T cell responses and achieving improved gastric cancer patient outcomes than with serplulimab and chemotherapy alone.
CONDITIONS
Official Title
Clinical Study of Taurine Combined With Neoadjuvant Chemo-Immunotherapy for Treatment of Locally Advanced Gastric Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 to 75 years, any gender
- Pathologically confirmed gastric or gastroesophageal junction adenocarcinoma with clinical TNM stage II or III, T3, N 650, M=0
- Expected survival of at least 3 months
- Tumor specimens PD-L1 positive with combined positive score (CPS) 61
- Presence of measurable lesions suitable for radical R0 resection after doctor evaluation
- Eastern Cooperative Oncology Group (ECOG) performance status score of 0 or 1
- Provided written informed consent after understanding study purpose and procedures
You will not qualify if you...
- Use of taurine agents within 1 month before starting study treatment or during the study
- Positive for HER-2
- Presence of gastrointestinal obstruction, active gastrointestinal bleeding, perforation, or difficulty swallowing
- Severe diseases affecting heart, lung, liver, kidney, endocrine, hematopoietic, or psychiatric systems making participation unsuitable
- HIV infection, AIDS, autoimmune diseases, or current use of immunosuppressants
- Any other severe acute or chronic diseases or conditions judged by investigators to increase risk or be unsuitable for the study
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 6 locations
1
Xi-jing Hospital
Xi'an, Shaanxi, China, 710032
Actively Recruiting
2
Tang-Du Hospital
Xi'an, Shaanxi, China, 710038
Actively Recruiting
3
Shaanxi Provincial People's Hospital
Xi'an, Shaanxi, China, 710068
Actively Recruiting
4
Xi 'an International Medical Center Hospital
Xi'an, Shaanxi, China, 710100
Actively Recruiting
5
The Second Affilated Hospital Of Xi'an Jiaotong University (Xibei Hospital)
Xi'an, Shaanxi, China
Actively Recruiting
6
Xi'an NO.3 hospital
Xi'an, Shaanxi, China
Actively Recruiting
Research Team
X
Xiaodi Zhao, MD, PhD
CONTACT
X
Xin Wang, MD, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here