Actively Recruiting
Clinical Study on TQH2722 Injection Combined With Background Therapy for Seasonal Allergic Rhinitis
Led by Shanghai Chia Tai Tianqing Pharmaceutical Technology Development Co., Ltd. · Updated on 2026-03-27
300
Participants Needed
30
Research Sites
49 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study is a multicenter, open-label, Phase II, single-arm clinical trial, with a planned enrollment of 200 to 300 subjects. Its primary objective is to evaluate the safety and efficacy of TQH2722 injection in the treatment of seasonal allergic rhinitis.
CONDITIONS
Official Title
Clinical Study on TQH2722 Injection Combined With Background Therapy for Seasonal Allergic Rhinitis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aged 18 to 75 years, any gender
- Diagnosed with seasonal allergic rhinitis
- Positive allergen test result
- Sufficient exposure to pollen during the pollen season
- History of poor control or dissatisfaction with seasonal allergic rhinitis symptoms during the previous pollen season
- Morning iTNSS score of 4 or higher on screening and baseline visits
- Average rTNSS score of 4 or higher over the past 6 days
- Good compliance during screening and induction period
- Stable medication use and asthma condition if comorbid asthma is present
- Voluntarily signed informed consent and show good compliance
- Agreement by subjects and partners to use effective contraception throughout the study and for 3 months after last drug administration
You will not qualify if you...
- Any abnormal lab test value during screening or randomization
- Unstable diseases that could affect safety, study results, or completion
- Active autoimmune diseases
- Known or suspected use of immunosuppressants
- Active malignant tumors or history of malignant tumors
- History of active tuberculosis within the past 12 months
- Active hepatitis or positive HIV or syphilis antibody during screening
- Helminthic parasitic infections within 6 months without effective treatment
- Recent specific medications or nasal/sinus surgery within specified timeframes
- IVIG therapy or plasma exchange within 30 days before screening
- Use of monoamine oxidase inhibitors within 14 days before screening
- Allergen immunotherapy initiated within 3 months prior to screening
- Receipt or planned receipt of attenuated live vaccines within 4 weeks before or during study
- Use of systemic Chinese herbal preparations or glucocorticoids within specified timeframes
- Chronic active or acute infection within 2 weeks before or during screening
- Asthma with FEV1 ≤ 50%, recent acute exacerbation, high-dose inhaled corticosteroids, or unstable status
- Diseases preventing completion of screening or efficacy evaluation
- Malignant or benign nasal cavity tumors
- Perennial allergic rhinitis with allergy to pet hair
- Inability to use nasal corticosteroids or antihistamines
- History of systemic allergy to biological agents
- Pregnancy or breastfeeding
- Alcohol or drug abuse or known dependency
- History of major organ or stem cell transplantation
- Medical or psychiatric conditions posing risk or interfering with study
- FEV1 ≤ 50% of predicted normal value
- Other reasons deemed inappropriate by investigator
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 30 locations
1
Peking University First Hospital
Beijing, Beijing Municipality, China, 100034
Not Yet Recruiting
2
Peking University People's Hospital
Beijing, Beijing Municipality, China, 100044
Not Yet Recruiting
3
Peking University Third Hospital
Beijing, Beijing Municipality, China, 100191
Actively Recruiting
4
The First Affiliated Hospital of Chongqing Medical University
Chongqing, Chongqing Municipality, China, 400010
Actively Recruiting
5
Hebei University Affiliated Hospital
Baoding, Hebei, China, 071000
Not Yet Recruiting
6
Cangzhou Central Hospital
Cangzhou, Hebei, China, 061017
Not Yet Recruiting
7
Hebei PetroChina Central Hospital
Langfang, Hebei, China, 65000
Not Yet Recruiting
8
Hebei Provincial People's Hospital
Shijiazhuang, Hebei, China, 050051
Not Yet Recruiting
9
Hebei Medical University Third Hospital
Shijiazhuang, Hebei, China, 50000
Not Yet Recruiting
10
The First Affiliated Hospital of Hebei North University
Zhangjiakou, Hebei, China, 075000
Not Yet Recruiting
11
Henan Provincial People's Hospital
Zhengzhou, Henan, China, 450000
Not Yet Recruiting
12
The Central Hospital of Wuhan
Wuhan, Hubei, China, 430014
Not Yet Recruiting
13
Union Hospital, Tongji Medical College, Huazhong University of science and technology
Wuhan, Hubei, China, 430022
Not Yet Recruiting
14
Tongji Hospital of Tongji medical college of HUST
Wuhan, Hubei, China, 430030
Not Yet Recruiting
15
Zhongnan Hospital of Wuhan University
Wuhan, Hubei, China, 430060
Not Yet Recruiting
16
The Second Affiliated Hospital of Xi'an Jiaotong University
Xi'an, Shaanxi, China, 710004
Not Yet Recruiting
17
The First Affiliated Hospital of Xi'an Jiaotong University
Xi'an, Shaanxi, China, 710061
Not Yet Recruiting
18
Yan'an University Xianyang Hospital
Xi'an, Shaanxi, China, 716000
Not Yet Recruiting
19
Shandong Second Provincial General Hospital
Jinan, Shandong, China, 250000
Not Yet Recruiting
20
Qilu Hospital of Shandong University
Jinan, Shandong, China, 250012
Not Yet Recruiting
21
Yantai Yuhuangding Hospital
Yantai, Shandong, China, 264000
Not Yet Recruiting
22
Zibo Central Hospital
Zibo, Shandong, China, 255036
Not Yet Recruiting
23
Shanxi Bethune Hospital
Taiyuan, Shanxi, China, 030000
Actively Recruiting
24
Hospital of Chengdu University of Traditional Chinese Medicine
Chengdu, Sichuan, China, 610000
Not Yet Recruiting
25
Second People's Hospital of Chengdu
Chengdu, Sichuan, China, 610000
Not Yet Recruiting
26
Tianjin People's Hospital
Tianjin, Tianjin Municipality, China, 300121
Not Yet Recruiting
27
The First Affiliated Hospital of Xinjiang Medical University
Ürümqi, Xinjiang, China
Not Yet Recruiting
28
The First Affiliated Hospital of Kunming Medical University
Kunming, Yunnan, China, 650032
Not Yet Recruiting
29
Yunnan Provincial Hospital of Chinese Medicine
Kunming, Yunnan, China, 650032
Not Yet Recruiting
30
Zhejiang Provincial People's Hospital
Hangzhou, Zhejiang, China, 310014
Not Yet Recruiting
Research Team
Z
Zheng Liu, Doctor
CONTACT
R
Rongfei Zhu, Doctor
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here