Clinical Efficacy of Long-Duration High-Voltage Pulsed Radiofrequency Combined with Dexmedetomidine Nasal Spray for Herpes Zoster Pain

What this Trial Is About

This clinical trial focuses on adults aged 40 to 85 years suffering from herpes zoster-associated neuropathic pain that has not responded well to conventional drug treatment. The study aims to evaluate the effects of combining dexmedetomidine nasal spray with long-duration high-voltage pulsed radiofrequency therapy compared to pulsed radiofrequency therapy alone. It is a randomized, controlled, phase 2 study designed to explore new treatment methods that may help reduce pain and improve patients' quality of life. Participants will be randomly assigned to one of two groups. The experimental group will receive dexmedetomidine nasal spray before the pulsed radiofrequency treatment, specifically before bedtime on the day of the procedure and for three nights afterward, in addition to standard drug treatment. The control group will receive only the long-duration high-voltage pulsed radiofrequency therapy along with conventional drug treatment. Heart rate, blood pressure, and blood oxygen levels will be closely monitored before, during, and after the procedure. During the study, participants will be evaluated using the Numerical Pain Rating Scale and the Hamilton Anxiety Scale at several time points: before treatment, and then 7, 30, 90, and 180 days afterward. Additional assessments include sleep quality, inflammation markers, and blood pressure measurements. Follow-up contacts will be conducted by phone at 1 week, 1 month, 3 months, and 6 months after treatment. Participants will provide medical history details and report any discomfort or issues during the study. Privacy and confidentiality of participant information will be maintained throughout the trial.

Clinical Study on the Treatment of Herpes Zoster Pain With Dexmedetomidine Combined With Long-term High Voltage