Actively Recruiting
A Clinical Study on the Treatment of LACC With Cadonilimab Combined With Chemotherapy Followed by CCRT
Led by Union Hospital, Tongji Medical College, Huazhong University of Science and Technology · Updated on 2026-05-13
378
Participants Needed
1
Research Sites
325 weeks
Total Duration
On this page
Sponsors
U
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Lead Sponsor
A
Akesobio
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study mainly evaluated the efficacy and safety of Cadonilimab combined with chemotherapy followed by concurrent chemoradiotherapy versus standard concurrent chemoradiotherapy in the treatment of locally advanced cervical cancer.
CONDITIONS
Official Title
A Clinical Study on the Treatment of LACC With Cadonilimab Combined With Chemotherapy Followed by CCRT
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Female, aged 18 to 70 years (inclusive)
- Histologically confirmed squamous cell carcinoma, adenocarcinoma, or adenosquamous carcinoma of the cervix
- Cervical cancer stage IIB to IVA (FIGO 2018) with no prior antineoplastic therapy
- At least one measurable tumor lesion per RECIST v1.1
- Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1
- Adequate organ function
You will not qualify if you...
- Presence of distant metastatic disease including specific lymph node metastasis (FIGO stage IVB)
- Prior total hysterectomy (removal of uterus body and cervix)
- Inability or refusal to undergo brachytherapy due to anatomical or other reasons
- Previous antineoplastic therapies such as surgery (except biopsy), radiotherapy, chemotherapy, immunotherapy, or targeted therapy
- Any condition deemed by investigators as unsuitable for trial participation
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Wuhan, Hubei, China
Actively Recruiting
Research Team
T
Ting Liu, MD
CONTACT
G
Guiling Li, PHD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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