Actively Recruiting

Phase 2
Age: 18Years - 80Years
All Genders
NCT07133633

A Clinical Study of Tulisokibart (MK-7240) to Treat Radiographic Axial Spondyloarthritis (MK-7240-013)

Led by Merck Sharp & Dohme LLC · Updated on 2026-05-12

315

Participants Needed

98

Research Sites

227 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

Researchers are looking for new ways to treat radiographic axial spondyloarthritis (r-axSpA). R-axSpA is a type of arthritis that causes pain, stiffness, and inflammation (swelling) in the spine and joints in the pelvis (hip bone). Radiographic means the damage it causes can be seen on X-rays. This study will help find out if a study medicine called tulisokibart can treat symptoms of r-axSpA. Researchers will look at different doses of tulisokibart. Researchers want to know if at least one of the study doses of tulisokibart works better than a placebo to improve r-axSpA symptoms. A placebo looks like the study medicine but has no study medicine in it. Using a placebo helps researchers better understand the effects of the study medicine.

CONDITIONS

Official Title

A Clinical Study of Tulisokibart (MK-7240) to Treat Radiographic Axial Spondyloarthritis (MK-7240-013)

Who Can Participate

Age: 18Years - 80Years
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Clinical diagnosis of axial spondyloarthritis meeting ASAS criteria with at least 3 months of back pain and symptom onset before age 45
  • Meets radiographic criteria of modified New York criteria for ankylosing spondylitis confirmed by central reading
  • Active disease present at screening and randomization
  • History of inadequate response or intolerance to NSAIDs and either biologic DMARD-naive or inadequate response/intolerance to up to 2 biologic DMARD classes
Not Eligible

You will not qualify if you...

  • Arthritis onset before age 17 or current diagnosis of inflammatory joint diseases other than r-axSpA (e.g., rheumatoid arthritis, lupus, psoriatic arthritis, systemic sclerosis, myositis)
  • History of cancer in the last 5 years except fully treated non-melanoma skin cancer or cervical carcinoma in situ after surgery
  • Any active infection
  • Known allergies, hypersensitivity, or intolerance to tulisokibart or its excipients

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 98 locations

1

AARA Clinical Research - Arizona Arthritis & Rheumatology Associates - Chandler ( Site 0036)

Chandler, Arizona, United States, 85225

Actively Recruiting

2

AARA Clinical Research - Arizona Arthritis & Rheumatology Associates - Flagstaff ( Site 0021)

Flagstaff, Arizona, United States, 86001

Actively Recruiting

3

Arizona Arthritis & Rheumatology Associates, P.C. - Gilbert ( Site 0022)

Gilbert, Arizona, United States, 85297

Actively Recruiting

4

AARA Arizona Arthritis & Rheumatology Associates, P.C. - Glendale ( Site 0056)

Glendale, Arizona, United States, 85306

Actively Recruiting

5

Arizona Arthritis & Rheumatology Associates, P.C. - Tucson ( Site 0025)

Tucson, Arizona, United States, 85704-1140

Actively Recruiting

6

TriWest Research Associates - Chula Vista ( Site 0013)

Chula Vista, California, United States, 91910

Actively Recruiting

7

Providence Medical Foundation ( Site 0049)

Fullerton, California, United States, 92835

Actively Recruiting

8

Newport Huntington Medical Group ( Site 0005)

Huntington Beach, California, United States, 92648

Actively Recruiting

9

Cohen Medical Centers ( Site 0034)

Thousand Oaks, California, United States, 91360-3967

Actively Recruiting

10

Inland Rheumatology Clinical Trials, Inc. ( Site 0002)

Upland, California, United States, 91786

Actively Recruiting

11

Arthritis and Rheumatic Disease Specialties ( Site 0016)

Aventura, Florida, United States, 33180

Actively Recruiting

12

Bay Area Arthritis and Osteoporosis ( Site 0041)

Brandon, Florida, United States, 33511

Actively Recruiting

13

GNP Research - Hollywood ( Site 0020)

Cooper City, Florida, United States, 33024

Actively Recruiting

14

Innovation Medical Research Center ( Site 0012)

Palmetto Bay, Florida, United States, 33157

Actively Recruiting

15

Chicago Arthritis & Regenerative Medicine ( Site 0042)

Chicago, Illinois, United States, 60661

Actively Recruiting

16

Willow Rheumatology and Wellness, PLLC ( Site 0035)

Willowbrook, Illinois, United States, 60527

Actively Recruiting

17

Arthritis and Rheumatism Associates - Rockville ( Site 0019)

Rockville, Maryland, United States, 20850

Actively Recruiting

18

Kansas City Physician Partners ( Site 0027)

Kansas City, Missouri, United States, 64111

Actively Recruiting

19

Velocity Clinical Research - West County Rheumatology, St. Louis ( Site 0038)

St Louis, Missouri, United States, 63131

Actively Recruiting

20

Physician Research Collaboration, LLC ( Site 0057)

Lincoln, Nebraska, United States, 68516-5497

Actively Recruiting

21

Inspire Santa Fe Medical Group ( Site 0011)

Santa Fe, New Mexico, United States, 87505

Actively Recruiting

22

Altoona Center for Clinical Research ( Site 0004)

Duncansville, Pennsylvania, United States, 16635

Actively Recruiting

23

Perelman Center for Advanced Medicine ( Site 0060)

Philadelphia, Pennsylvania, United States, 19104

Actively Recruiting

24

AARA Clinical Research - Murfreesboro Medical Clinic ( Site 0029)

Murfreesboro, Tennessee, United States, 37128

Actively Recruiting

25

Rheumatology Associates ( Site 0055)

Arlington, Texas, United States, 76012

Actively Recruiting

26

Arthritis Care of Texas ( Site 0048)

Corpus Christi, Texas, United States, 78415

Actively Recruiting

27

Lone Star Arthritis & Rheumatology Associates, P.C. ( Site 0028)

Fort Worth, Texas, United States, 76109

Actively Recruiting

28

Provecta Research Network LLC ( Site 0054)

Houston, Texas, United States, 77027

Actively Recruiting

29

AARA Clinical Research - Lone Star Arthritis and Rheumatology Associates - Irving ( Site 0032)

Irving, Texas, United States, 75039

Actively Recruiting

30

Epic Medical Research ( Site 0061)

Red Oak, Texas, United States, 75154

Actively Recruiting

31

Advanced Rheumatology of Houston ( Site 0001)

The Woodlands, Texas, United States, 77382

Actively Recruiting

32

DM Clinical Research - TRA ( Site 0010)

Tomball, Texas, United States, 77375

Actively Recruiting

33

CMIP-CENTRO MINEIRO DE PESQUISA ( Site 1999)

Juiz de Fora, Minas Gerais, Brazil, 36010-570

Actively Recruiting

34

Complexo Hospital de Clínicas da Universidade Federal do Paraná ( Site 1991)

Curitiba, Paraná, Brazil, 80060-900

Actively Recruiting

35

LMK Serviços Médicos S/S ( Site 2000)

Porto Alegre, Rio Grande do Sul, Brazil, 90480-000

Actively Recruiting

36

IBPClin - Instituto Brasil de Pesquisa Clínica ( Site 1994)

Rio de Janeiro, Brazil, 20241-180

Actively Recruiting

37

Centro de Pesquisas Clínicas do Hospital das Clínicas de São Paulo ( Site 1992)

São Paulo, Brazil, 05403-000

Actively Recruiting

38

G.R.M.O. (Groupe de recherche en maladies osseuses) Inc. ( Site 0200)

Québec, Quebec, Canada, G1V 3M7

Actively Recruiting

39

Centre de Recherche Musculo-Squelettique ( Site 0202)

Trois-Rivières, Quebec, Canada, G9A 3Y2

Actively Recruiting

40

Bioreuma ( Site 2109)

Concepción, Biobio, Chile, 4070280

Actively Recruiting

41

Clinica Alemana Osorno ( Site 2114)

Osorno, Los Lagos Region, Chile, 5311089

Actively Recruiting

42

Centro de Estudios GyC ( Site 2103)

Santiago, Region M. de Santiago, Chile, 7500504

Actively Recruiting

43

Enroll SpA ( Site 2101)

Santiago, Region M. de Santiago, Chile, 7500587

Actively Recruiting

44

Bradfordhill ( Site 2110)

Santiago, Region M. de Santiago, Chile, 8420383

Actively Recruiting

45

The First Afflilated Hospital of Bengbu Medical College ( Site 3119)

Bengbu, Anhui, China, 233004

Actively Recruiting

46

Chinese Academy of Medical Science Peking Union Medical College Hospital ( Site 3100)

Beijing, Beijing Municipality, China, 100005

Actively Recruiting

47

Guangdong Provincial People's Hospital ( Site 3110)

Guangzhou, Guangdong, China, 510080

Actively Recruiting

48

The Third Affiliated Hospital of Sun Yat-Sen University ( Site 3114)

Guangzhou, Guangdong, China, 510630

Actively Recruiting

49

The First Affiliated Hospital of Henan University of Science &Technology ( Site 3121)

Luoyang, Henan, China, 471003

Actively Recruiting

50

Pingxiang People's Hospital ( Site 3115)

Pingxiang, Jiangxi, China, 337055

Actively Recruiting

51

The First Hospital Of Jilin University ( Site 3103)

Changchun, Jilin, China, 130021

Actively Recruiting

52

PEOPLE'S HOSPITAL OF XINJIANG UYGUR AUTONOMOUS REGION ( Site 3124)

Ürümqi, Xinjiang, China, 830001

Actively Recruiting

53

First Affiliated Hospital of Kunming Medical University ( Site 3123)

Kunming, Yunnan, China, 650032

Actively Recruiting

54

Clinica de la Costa S.A.S. ( Site 2202)

Barranquilla, Atlántico, Colombia, 080020

Actively Recruiting

55

CIREEM SAS ( Site 2204)

Bogota, Cundinamarca, Colombia, 110221

Active, Not Recruiting

56

Fundación Valle del Lili ( Site 2201)

Cali, Valle del Cauca Department, Colombia, 760032

Actively Recruiting

57

Medicover München Ost MVZ ( Site 0611)

Munich, Bavaria, Germany, 81667

Actively Recruiting

58

Rheumazentrum Ruhrgebiet ( Site 0600)

Herne, North Rhine-Westphalia, Germany, 44649

Actively Recruiting

59

Rheumazentrum Ratingen Studienambulanz ( Site 0602)

Ratingen, North Rhine-Westphalia, Germany, 40878

Actively Recruiting

60

Rheumatologische Schwerpunktpraxis ( Site 0605)

Berlin, Germany, 12161

Actively Recruiting

61

Charite Universitätsmedizin Berlin Campus Benjamin Franklin-Medizinische Klinik I für Gastroenterol ( Site 0601)

Berlin, Germany, 12203

Actively Recruiting

62

HRF II - Hamburger Rheuma Forschungszentrum II MVZ für Rheumatologie und Autoimmunmedizin Hamburg G ( Site 0604)

Hamburg, Germany, 20095

Actively Recruiting

63

Zuyderland Medical Centre ( Site 1100)

Heerlen, Limburg, Netherlands, 6419 PC

Actively Recruiting

64

Amsterdam UMC ( Site 1101)

Amsterdam, North Holland, Netherlands, 1081 HV

Actively Recruiting

65

Maasstad Ziekenhuis ( Site 1102)

Rotterdam, South Holland, Netherlands, 3079DZ

Actively Recruiting

66

MICS Centrum Medyczne Bydgoszcz ( Site 1206)

Bydgoszcz, Kuyavian-Pomeranian Voivodeship, Poland, 85-065

Actively Recruiting

67

Szpital Uniwersytecki Nr 2 im. dr J. Biziela w Bydgoszczy ( Site 1203)

Bydgoszcz, Kuyavian-Pomeranian Voivodeship, Poland, 85-168

Actively Recruiting

68

MICS Centrum Medyczne Torun ( Site 1202)

Torun, Kuyavian-Pomeranian Voivodeship, Poland, 87-100

Actively Recruiting

69

Zespół Poradni Specjalistycznych Reumed Filia nr 1 Wallenroda ( Site 1201)

Lublin, Lublin Voivodeship, Poland, 20-607

Actively Recruiting

70

MICS Centrum Medyczne Warszawa ( Site 1204)

Warsaw, Masovian Voivodeship, Poland, 00-874

Actively Recruiting

71

Narodowy Instytut Geriatrii Reumatologii i Rehabilitacji im.Prof. El. Reicher-ul.Spartanska 1 ( Site 1205)

Warsaw, Masovian Voivodeship, Poland, 02-637

Actively Recruiting

72

Hanyang University Seoul Hospital ( Site 2800)

Seoul, South Korea, 04763

Actively Recruiting

73

Kyung Hee University Hosptial at Gangdong ( Site 2802)

Seoul, South Korea, 05278

Actively Recruiting

74

Taipei Medical University Shuang Ho Hospital ( Site 2900)

New Taipei City, New Taipei, Taiwan, 235

Actively Recruiting

75

National Taiwan University Hospital ( Site 2902)

Taipei City, Taipei, Taiwan, 100

Actively Recruiting

76

Kaohsiung Veterans General Hospital ( Site 2905)

Kaohsiung City, Taiwan, 813414

Actively Recruiting

77

Chang Gung Memorial Hospital at Kaohsiung ( Site 2908)

Kaohsiung City, Taiwan, 833

Actively Recruiting

78

National Cheng Kung University Hospital ( Site 2903)

Tainan, Taiwan, 704

Actively Recruiting

79

Taipei Veterans General Hospital ( Site 2906)

Taipei, Taiwan, 112

Actively Recruiting

80

Chang Gung Memorial Hospital - Linkou Branch ( Site 2904)

Taoyuan, Taiwan, 33305

Actively Recruiting

81

Istanbul University Cerrahpasa Medical School Internal Diseases Institute ( Site 1604)

Fatih, Istanbul, Turkey (Türkiye), 34098

Actively Recruiting

82

ANKARA UNIVERSITY IBNI SINA HOSPITAL ( Site 1600)

Ankara, Turkey (Türkiye), 06230

Actively Recruiting

83

Hacettepe Universite Hastaneleri ( Site 1603)

Ankara, Turkey (Türkiye), 06230

Actively Recruiting

84

Kocaeli Üniversitesi ( Site 1605)

Kocaeli, Turkey (Türkiye), 41380

Actively Recruiting

85

Konya Necmettin Erbakan Universitesi ( Site 1606)

Konya, Turkey (Türkiye), 42090

Actively Recruiting

86

Communal Nonprofit Enterprise Cherkasy Regional Hospital of Cherkasy Oblast Council ( Site 1704)

Cherkasy, Chernivetska Oblast, Ukraine, 18009

Actively Recruiting

87

Municipal Public Non-Profit Enterprise "City Clinical Hospital №1 of the Ivano-Frankivsk City Counc ( Site 1705)

Ukraine, Ivano-Frankivsk Oblast, Ukraine, 76018

Actively Recruiting

88

Municipal Non-Profit Enterprise "Khmelnytskyi Regional Hospital" of Khmelnytskyi Regional Council ( Site 1713)

Khmelnytskiy, Khmelnytskyi Oblast, Ukraine, 29000

Actively Recruiting

89

Medical Center of Limited Liability Company "Medical Center "Consilium Medical" ( Site 1715)

Kyiv, Kyivska Oblast, Ukraine, 04050

Actively Recruiting

90

Lviv Clin Hospital of Planned Treatment Rehabilitation Palliative Care ( Site 1710)

Lviv, Lviv Oblast, Ukraine, 79011

Actively Recruiting

91

ME "Ternopil Regional Clinical Hospital of Ternopil Regional Council" ( Site 1707)

Ternopil, Ternopil Oblast, Ukraine, 46002

Actively Recruiting

92

Municipal Nonprofit Enterprise "Vinnytsia Regional Clinical Hospital n.a. M. I. Pyrohov of Vinnytsia ( Site 1700)

Vinnytsa, Vinnytsia Oblast, Ukraine, 21018

Actively Recruiting

93

Kyiv Railway Clinical Hospital No.2 of Branch Health Center of the Public Joint Stock Company Ukrain ( Site 1701)

Kyiv, Ukraine, 03049

Actively Recruiting

94

Medical Center "Universal Clinic "Oberig" of Limited Liability Company "Kapytal" ( Site 1706)

Kyiv, Ukraine, 03057

Actively Recruiting

95

Norfolk & Norwich University Hospital NHS Foundation Trust ( Site 1800)

Norwich, Norfolk, United Kingdom, NR4 7UY

Actively Recruiting

96

Royal United Hospital Bath NHS Foundation Trust ( Site 1803)

Bath, Somerset, United Kingdom, BA1 3NG

Actively Recruiting

97

Barnet Hospital ( Site 1806)

Barnet, United Kingdom, EN5 3DJ

Actively Recruiting

98

St Luke's Hospital ( Site 1801)

Bradford, United Kingdom, BD5 0NA

Actively Recruiting

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Research Team

T

Toll Free Number

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

TRIPLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

4

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